After absorption, most drugs will distribute heterogeneouslyacross tissues and organs, with the total drug concentration in plasmagenerally not being representative of the total concentration in other tissues.The main ...

The free drug theory (sometimes also termed free drug hypothesis) provides a conceptual framework increasingly used to understand pharmacokinetics/pharmacodynamics (PK/PD) relationships [1]. It underlines the central role ...

Biopharmaceutics and pharmacokinetics are pharmaceutical disciplines useful to improve the outcome of drug therapies, assist drug product development, and establish pharmacokinetics-pharmacodynamics models and in vitro-in ...

Hypothesis: Doxorubicin hydrochloride (DX) is widely used as a chemotherapeutic agent, though its severe side-effects limit its clinical use. A way to overcome these limitations is to increase DX latency through encapsulation ...

The development of organic synthesis represents an important advance in the discovery of new drugs, being considered an important step in medicinal chemistry. However, the preparation and optimization of drugs is considered ...

Neuralgia, is a symptom of some neurological disorders and can be found at any age. It is characterized by paroxysmal and lancinating pain that follows the path of the affected nerve. It can be spontaneous or may be triggered ...

Objective: To evaluate the marginal microleakage in enamel and dentin/cementum walls in preparations with a high C-factor, using 3 resin composite insertion techniques. The null hypothesis was that there is no difference ...