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Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein
(Landes Bioscience, 2009-05)
Both sequence-specific DNA binding and exonuclease activities have been mapped to the central conserved core domain of p53. To gain more information about these two activities a series of mutants were generated that changed ...
Caracterização molecular da atividade de interação da proteína RPA-1 com os telômeros de Leishmania spp.
(Universidade Estadual Paulista (Unesp), 2018-04-27)
Entre as espécies do gênero Leishmania estão os protozoários que causam leishmaniose, uma doença tropical negligenciada endêmica em muitos países, incluindo o Brasil. Métodos de controle e tratamento ainda são ineficientes ...
Accuracy of replication in the polymerase chain reaction. Comparison between Thermotoga maritima DNA polymerase and Thermus aquaticus DNA polymerase
(Associação Brasileira de Divulgação Científica, 1998-10-01)
For certain applications of the polymerase chain reaction (PCR), it may be necessary to consider the accuracy of replication. The breakthrough that made PCR user friendly was the commercialization of Thermus aquaticus (Taq) ...
Rad51 prevents Mre11-dependent degradation and excessive primpol-mediated elongation of nascent DNA after UV irradiation
(National Academy Of Sciences, 2015-12)
After UV irradiation, DNA polymerases specialized in translesion DNA synthesis (TLS) aid DNA replication. However, it is unclear whether other mechanisms also facilitate the elongation of UV-damaged DNA. We wondered if ...
Sofosbuvir terminated RNA is more resistant to SARS‐CoV‐2 proofreader than RNA terminated by Remdesivir
SARS-CoV-2 is responsible for COVID-19, resulting in the largest pandemic in over a hundred years.
After examining the molecular structures and activities of hepatitis C viral inhibitors and comparing
hepatitis C virus ...
DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression
(National Academy Of Sciences, 2016-07)
DNA damage tolerance facilitates the progression of replication forks that have encountered obstacles on the template strands. It involves either translesion DNA synthesis initiated by proliferating cell nuclear antigen ...
Avaliação do potencial de mutagenicidade e toxidade da lectina hipoglicemiante de folha de Bauhinia monandra (pata-de-vaca)
(Universidade Federal do Rio Grande do NorteBRUFRNPrograma de Pós-Graduação em Ciências da SaúdeCiências da Saúde, 2009-05-08)
Medicinal plants have been used since antiquity to treat various human diseases. The leaves of Bauhinia monandra are widely used in Brazil as herbal remedies in the treatment of Diabetes Mellitus. From the leaves of B. ...
Sterol regulatory element-binding protein Sre1 regulates carotenogenesis in the red yeast Xanthophyllomyces dendrorhous
(Amer Soc Biochemistry Molecular Biology, 2020)
Xanthophyllomyces dendrorhous is a basidiomycete
yeast that produces carotenoids, mainly astaxanthin. Astaxanthin
is an organic pigment of commercial interest due to
its antioxidant and coloring properties. X. dendrorhous ...