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Quick Detection of FKS1 Mutations Responsible for Clinical Echinocandin Resistance in Candida albicans
(American Society for Microbiology, 2015-07)
A rapid molecular-based assay for the detection of the Candida albicans FKS1 gene mutations responsible for resistance to echinocandin drugs was designed and evaluated. The assay consisted of a multiplexed PCR set of 5 ...
Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance
(University of Chicago Press, 2011-08)
The identification of FKS1 mutations in Candida albicans associated with echinocandin resistance has raised concerns over the spread of drug-resistant strains. We studied the impact of fks1 mutations on C. albicans virulence ...
Improved Detection of Candida spp. fks Hot Spot Mutants by Using the Method of the CLSI M27-A3 Document with the Addition of Bovine Serum Albumin
(American Society For Microbiology, 2011-03)
Echinocandins are highly bound to serum proteins, altering their antifungal properties. The addition of 50% human serum to the MIC assay improves the identification of echinocandin-resistant Candida spp. harboring fks hot ...
Phenotypic and molecular evaluation of echinocandin susceptibility of Candida glabrata, Candida bracarensis, and Candida nivariensis strains isolated during 30 years in Argentina
(American Society for Microbiology, 2017-07)
The echinocandin susceptibilities of 122 Candida glabrata complex strains (including 5 Candida nivariensis and 3 Candida bracarensis strains) were evaluated by microdilution and compared with the results from a molecular ...
Rezafungin—mechanisms of action, susceptibility and resistance: Similarities and differences with the other echinocandins
(MDPI AG, 2020-12)
Rezafungin (formerly CD101) is a new β-glucan synthase inhibitor that is chemically related with anidulafungin. It is considered the first molecule of the new generation of long-acting echinocandins. It has several advantages ...
Subunidades Fksp del complejo beta-1,3- D-glucan sintasa de Candida glabrata: rol en la síntesis de la pared celular, en la resistencia a las equinocandinas y como marcadores de resistencia clínica
(2017-03-17)
Las infecciones causadas por levaduras del complejo Candida glabrata son un desafío terapéutico, ya que adquieren fácilmente resistencia a los triazoles y tienen sensibilidad reducida a los polienos. Por estas razones, las ...
Loss of C-5 sterol desaturase activity results in increased resistance to azole and echinocandin antifungals in a clinical isolate of Candida parapsilosis.
(Estados Unidos : Antimicrobial Agents and Chemotherapy, 2017., 2019-09-24)
Among emerging non-albicans Candida species, Candida parapsilosis is of particular concern as a cause of nosocomial bloodstream infections in neonatal and intensive care unit patients. While fluconazole and echinocandins ...
Candida parapsilosis: resistência as equinocandinas e a suscetibilidade a antifúngicos isolados e em combinação
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2016-08-05)
Candida parapsilosis is a yeast fungus that causes a wide spectrum of infections
predominantly in immunocompromised patients and representing a major cause of
infections related to health care. The emergence of resistance ...
Set of Classical PCRs for Detection of Mutations in Candida glabrata FKS Genes Linked with Echinocandin Resistance
(American Society for Microbiology, 2014-07)
Clinical echinocandin resistance among Candida glabrata strains is increasing, especially in the United States. Antifungal susceptibility testing is considered mandatory to guide therapeutic decisions. However, these ...