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A importância da análise histológica morfométrica gonadal na identificação da gônada disgenéticaGonadal dysgenesis and morphometric histologic analysis
(Sociedade Brasileira de Endocrinologia e Metabologia, 2003)
Morphometry and histology of gonads from 13 children with dysgenetic male pseudohermaphroditism
(Coll Amer Pathologists, 2001-05-01)
Background.-Dysgenetic male pseudohermaphroditism (DMP) is a sexual differentiation disorder characterized by bilateral dysgenetic testes, persistent mullerian structures, and cryptorchidism in individuals with a 46,XY ...
OCT4 immunohistochemistry may be necessary to identify the real risk of gonadal tumors in patients with Turner syndrome and Y chromosome sequences
(Oxford Univ PressOxfordInglaterra, 2011)
Disgenesias gonadais e tumores: aspectos genéticos e clínicos
(Sociedade Brasileira de Endocrinologia e Metabologia, 2005-02-01)
Gonadal dysgenesis comprises a clinical spectrum of anomalies in patients with female, ambiguous or male phenotype, absent or impaired puberty and karyotype with or without Y chromosome and/or chromosome markers. Although ...
OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome
(Elsevier B.V., 2010-11-01)
To show that in the dysgenetic gonads of 104 Turner syndrome patients no significant difference was found regarding the expression of the genes DAX1, FOG2, GATA4, OCT4, SF1, SRY, TSPY, WT1, and STRA8 compared with controls, ...
SRY Gene Increases the Risk of Developing Gonadoblastoma and/or Nontumoral Gonadal Lesions in Turner Syndrome
(Lippincott Williams & Wilkins, 2009-03-01)
The presence of Y-chromosome material in patients with dysgenetic gonads increases the risk of gonadal tumors and/or nontumoral androgen-producing lesions. the patients' prognosis can vary, depending oil their karyotype. ...
Absence of inactivating mutations and deletions in the DMRT1 and FGF9 genes in a large cohort of 46,XY patients with gonadal dysgenesis
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Despite advances in our understanding of the mechanisms involved in sex determination and differentiation, the specific roles of many genes in these processes are not completely understood in humans. Both DMRT1 and FGF9 ...