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Redirecionamento de fármacos e sinergia de medicamentos não-antibióticos e antibióticos no tratamento de doenças infecciosas
(Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2018-09-13)
The indiscriminate use of antimicrobials in monotherapy has led to the emergence of
multiresistant bacterial strains, which are also one of the greatest threats to human health.
Whiles antibiotic resistance presents ...
Reposicionamento dos antidepressivos fluoxetina e paroxetina e efeitos sinérgicos com ciprofloxacino frente bactérias multidroga resistentes
(Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2020-08-28)
The growing need for effective antimicrobial agents for the treatment of multidrug-resistant bacteria (MDR), mainly caused by nosocomial infections, leads to the use of alternative alternatives. The repositioning or ...
Reposicionamento de medicamentos em oncologia e doenças infecciosas: avaliação da atividade biológica de dissulfiram e ebselen
(Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2022-02-18)
Efforts are currently being invested in discovering more effective, selective and innovative antineoplastic and antimicrobial therapies. An alternative, faster process may arise through repositioning, also called drug ...
Modern Strategies in Cancer Study: Drug Repositioning in Colorectal Cancer Treatment
(Crimson Publisher, 2019-05)
Colorectal cancer is one of the most fatal cancers in the world because most of cases are diagnosed in advanced stages, when the development of resistance to chemotherapy is more frequent. To face this situation, new drugs ...
Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis
(Springer, 2020-01-22)
Melatonin has the ability to intervene in the initiation, progression and metastasis of some experimental cancers. A large variety of potential mechanisms have been advanced to describe the metabolic and molecular events ...
Reposicionamento de medicamentos em doenças infecciosas e avaliação da atividade biológica de inibidores da bomba de prótons e benzodiazepínicos
(Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2022-09-22)
A pathological condition with a high level of severity, caused by drug resistance, is one of the major public health
problems worldwide and has worrying consequences. This scenario becomes more complex when we mention ...
Reposicionamento dos antidepressivos fluoxetina e paroxetina
(Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2022-08-23)
The substantial increase in multidrug resistant (MDR) bacteria makes efforts to find more effective antimicrobial therapies urgent. Drug repositioning, defined as the process of investigating new uses for drugs that have ...
Reposicionamento dos antidepressivos e avaliação da atividade antibacteriana e de nuclease química in vitro de oxalato de escitalopram e clonazepam
(Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2019-08-22)
The emergence of multiresistance to commercially available antimicrobials today is likely to
continue to be one of the major global public health problems, as it has worrying clinical and
economic consequences. Concomitant ...
Avaliação da atividade biológica in vitro de triazenos, sertralina e metildopa como alternativas no reaproveitamento de medicamentos
(Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2021-04-19)
Currently, countless efforts to discover effective, selective and innovative antineoplastic and antimicrobial therapies have led to the synthesis and investigation of the biological activity of different molecules. Triazenes ...
Uso indiscriminado de benzodiazepínico: proposta de intervenção
(Universidade Federal de Minas GeraisUFMG, 2014-06-07)
Benzodiazepines ( BZDs ) are psychoactive drugs classically used to treat anxiety and sleep disorders. Became available from the 1960s and, since then, are among the most prescribed in the world. It is estimated that 50 ...