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Glucose Increase DAGLα Levels in Tanycytes and Its Inhibition Alters Orexigenic and Anorexigenic Neuropeptides Expression in Response to Glucose
(2019-09-20)
The endocannabinoid system (ECS) is composed of a group of Gi-coupled protein receptors and enzymes, producing and degrading the endocannabinoids, 2-arachidonoylglycerol (2-AG) and N-arachidonoyl-ethanolamine (AEA). ...
Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia
(Elsevier Ireland, 2017-07)
Endocannabinoids (eCBs) and acylethanolamides (AEs) have lately received more attention due to their neuroprotective functions in neurological disorders. Here we analyze the alterations induced by perinatal asphyxia (PA) ...
Planejamento e síntese de novos candidatos a inibidores da enzima sn-1-diacilglicerol lipase alfa (DAGL-α)
(Universidade Estadual Paulista (Unesp), 2017-02-21)
A obesidade tem sido relatada como um processo inflamatório em decorrência da presença de tecido adiposo visceral, promovendo a resistência à insulina, devido a isso, a obesidade é capaz de desencadear um conjunto de doenças. ...
Estudos computacionais e síntese de derivados sulfonamídicos candidatos a inibidores da enzima sn-1-diacilglicerol lipase alfa (DAGL-alfa) para o tratamento da obesidade
(Universidade Estadual Paulista (Unesp), 2019-08-28)
Segundo dados da Organização Mundial da Saúde, cerca de 13% da população mundial é classificada como obesa (2016). Consequentemente, há um elevado gasto em saúde para os cofres públicos e para a população de modo geral, ...
Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia
(Elsevier Ireland Ltd, 2017)
Cocaine-induced behavioral sensitization decreases the expression of endocannabinoid signaling-related proteins in the mouse hippocampus
(Elsevier Inc, 2016-03)
In the reward mesocorticolimbic circuits, the glutamatergic and endocannabinoid systems are implicated in neurobiological mechanisms underlying cocaine addiction. However, the involvement of both systems in the hippocampus, ...
Reconstrucción filogenética del sistema endocannabinoide y estudio de sectores proteicos del receptor CB1.
(Universidad de Concepción.Facultad de Ciencias Naturales y Oceanográficas, 2021)
El sistema de endocannabinoides (SEC) presenta componentes que se distribuyen
en los distintos reinos en los que se organiza la naturaleza. Estudios previos
sugieren un origen putativo de los distintos componentes del ...
The Endocannabinoid System Is Present in Rod Outer Segments from Retina and Is Modulated by Light
(Springer, 2019-04-24)
The aim of the present research was to evaluate if the endocannabinoid system (enzymes and receptors) could bemodulated by light in rod outer segment (ROS) from bovine retina. First, we analyzed endocannabinoid ...
Perinatal asphyxia results in altered expression of the hippocampal acylethanolamide/endocannabinoid signaling system associated to memory impairments in postweaned rats
(Frontiers Research Foundation, 2015-11)
Perinatal asphyxia (PA) is an obstetric complication that strongly affects the CNS. The endocannabinoid system (ECS) is a lipid transmitter system involved in several physiological processes including synaptic plasticity, ...