info:eu-repo/semantics/article
Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia
Fecha
2017-07Registro en:
Holubiec, Mariana Ines; Romero, Juan Ignacio; Blanco, Eduardo; Logica Tornatore, Tamara Maite Ayelén; Suarez, Juan; et al.; Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia; Elsevier Ireland; Neuroscience Letters; 653; 7-2017; 269-275
0304-3940
1872-7972
CONICET Digital
CONICET
Autor
Holubiec, Mariana Ines
Romero, Juan Ignacio
Blanco, Eduardo
Logica Tornatore, Tamara Maite Ayelén
Suarez, Juan
Rodríguez de Fonseca, Fernando
Galeano, Pablo
Capani, Francisco
Resumen
Endocannabinoids (eCBs) and acylethanolamides (AEs) have lately received more attention due to their neuroprotective functions in neurological disorders. Here we analyze the alterations induced by perinatal asphyxia (PA) in the main metabolic enzymes and receptors of the eCBs/AEs in the dorsal striatum of rats. To induce PA, we used a model developed by Bjelke et al. (1991). Immunohistochemical techniques were carried out to determine the expression of neuronal and glial markers (NeuN and GFAP), eCBs/AEs synthesis and degradation enzymes (DAGLα, NAPE-PLD and FAAH) and their receptors (CB1 and PPARα). We found a decrease in NAPE-PLD and PPARα expression. Since NAPE-PLD and PPARα take part in the production and reception of biochemical actions of AEs, such as oleoylethanolamide, these results may suggest that PA plays a key role in the regulation of this system. These data agree with previous results obtained in the hippocampus and encourage us to develop further studies using AEs as potential neuroprotective compounds.