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An update of biocatalytic selective acylation and deacylation of monosaccharides
(Royal Society of Chemistry, 2016-03)
Partially acylated monosaccharides (PAMs) exhibit diverse and interesting applications but due to their polyhydroxylated nature, their synthesis requires regio- and stereoselective reactions. These features are provided ...
2-Bromopalmitate Reduces Protein Deacylation by Inhibition of Acyl-Protein Thioesterase Enzymatic Activities
(Public Library Science, 2013-10)
S-acylation, the covalent attachment of palmitate and other fatty acids on cysteine residues, is a reversible post-translational modification that exerts diverse effects on protein functions. S-acylation is catalyzed by ...
Individual S-acylated cysteines differentially contribute to H-Ras endomembrane traffcking and acylation/deacylation cycles
(American Society for Cell Biology, 2017-04)
S-acylation/deacylation cycles and vesicular transport are critical for an adequate subcellular distribution of S-acylated Ras proteins. H-Ras is dually acylated on cysteines 181 and 184, but it is unknown how these residues ...
Characterization of native and deacylated Lipid A from lipooligosaccharide of Neisseria meningitidis Serogroup B
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2015)
Microbial hydrolysis of acetylated nucleosides
(Springer, 2006-07)
Enzymatic hydrolysis of acetylated nucleosides using microbial whole cells has been carried out for the first time. Unlike Candida antarctica B lipase-catalysed alcoholysis, none of the tested microorganisms displayed a ...
Dopaminergic Neurons Respond to Iron-Induced Oxidative Stress by Modulating Lipid Acylation and Deacylation Cycles
(Public Library Of Science, 2015-06)
Metal-imbalance has been reported as a contributor factor for the degeneration of dopami-nergic neurons in Parkinson Disease (PD). Specifically, iron (Fe)-overload and copper (Cu)mis-compartmentalization have been reported ...
Characterization of native and deacylated Lipid A from lipooligosaccharide of Neisseria meningitidis Serogroup B
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2018)
Mechanism of Heparin Acceleration of Tissue Inhibitor of Metalloproteases-1 (TIMP-1) Degradation by the Human Neutrophil Elastase
(PUBLIC LIBRARY SCIENCE, 2011)
Heparin has been shown to regulate human neutrophil elastase (HNE) activity. We have assessed the regulatory effect of heparin on Tissue Inhibitor of Metalloproteases-1 [TIMP-1] hydrolysis by HNE employing the recombinant ...
Hydrolytic mechanism of OXA-58 enzyme, a carbapenem-hydrolyzing class D β-lactamase from Acinetobacter baumannii
(American Society for Biochemistry and Molecular Biology, 2011-10)
Carbapenem-hydrolyzing class D β-lactamases (CHDLs) represent an emerging antibiotic resistance mechanism encountered among the most opportunistic Gram-negative bacterial pathogens. We report here the substrate kinetics ...
Reaction Mechanism of the PET Degrading Enzyme PETase Studied with DFT/MM Molecular Dynamics Simulations
(2021)
Polyethylene terephthalate (PET) has been widely used to make disposable bottles, among others, leading to massive PET waste accumulation in the environment. The discovery of the Ideonella sakaiensis PETase and MHETase ...