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Mostrando ítems 1-10 de 17
Synthesis, cytotoxicity and in vitro antileishmanial activity of naphthothiazoles
(2013-06-01)
The leishmaniasis is a spectral disease caused by the protozoan Leishmania spp., which threatens millions of people worldwide. Current treatments exhibit high toxicity, and there is no vaccine available. The need for new ...
Synthesis, cytotoxicity and in vitro antileishmanial activity of naphthothiazoles
(2013-06-01)
The leishmaniasis is a spectral disease caused by the protozoan Leishmania spp., which threatens millions of people worldwide. Current treatments exhibit high toxicity, and there is no vaccine available. The need for new ...
In vitro leishmanicidal activity of novel N-arylspermidine derivatives
(Universidad de Buenos Aires, 2019)
Visceral leishmaniasis (VL) is the second-largest parasitic killer disease in the world, responsiblefor near one million infections each year. Polyamines are ubiquitous organic molecules that play key roles in kinetoplastids ...
β-Carboline derivatives as novel antivirals for herpes simplex virus
(Elsevier Science, 2018-10)
Several commercial and novel synthetic β-carbolines (βCs) were evaluated for their antiviral activity against herpes simplex virus type 1 (HSV-1) using an adapted MTS assay. Of 21 drugs tested, although 11 exerted antiviral ...
Trypanocidal properties, structure-activity relationship and computational studies of quinoxaline 1,4-di-N-oxide derivatives
(Elsevier, 2011)
Pyrazole and propenone quinoxaline derivatives were tested against intracellular forms of Leishmania peruviana and Trypanosoma cruzi. Both series were tested for toxicity against proliferative and non-proliferative cells. ...