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The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo
(Dove Medical Press Ltd., 2018)
Food consumption, cytochrome P450 3A4 (CYP3A4) presystemic inhibitors, and bioavailability of saquinavir
(Sociedad Española de Farmacia Hospitalaria (SEFH)ElsevierPromoción y Prevención FarmacéuticaMadrid, España, 2021)
Role of cytochrome P450 enzymes in the metabolism of antineoplastic drugs Papel de las enzimas citocromo p450 en el metabolismo de fármacos antineoplásicos: Situación actual y perspectivas terapéuticas
(2008)
Cytochrome P450 enzymes are very important to metabolize anti-carcinogenic agents. Therefore, understanding the role of these enzymes and their allele variants in the bioactivation or detoxification of drugs could greatiy ...
Elucidation of cladofulvin biosynthesis reveals a cytochrome P450 monooxygenase required for anthraquinone dimerization
(National Academy of Sciences, 2016)
Anthraquinones are a large family of secondary metabolites (SMs) that are extensively studied for their diverse biological activities. These activities are determined by functional group decorations and the formation of ...
Papel de las enzimas citocromo p450 en el metabolismo de fármacos antineoplásicos: Situación actual y perspectivas terapéuticas
(Sociedad Médica de Santiago, 2008)
Effect of two wheat cultivars differing in hydroxamic acid concentration on detoxification metabolism in the aphid Sitobion avenae
(2000)
Hydroxamic acids (Hx) are wheat secondary metabolites conferring resistance for cereals against aphids. The activity of five enzymatic systems were evaluated in the aphid Sitobion avenae reared on the high-Hx wheat cultivar ...
Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism
(2010)
Melatonin, an endogenous hormone, is used as an antioxidant drug in doses quite higher than the endogenous circulating levels of this hormone. Hepatic endoplasmic reticulum contains the cytochrome P450 (CYP450) system, ...
Mechanisms underlying the inhibition of the cytochrome P450 system by copper ions
(2009)
Copper toxicity has been associated to the capacity of free copper ions to catalyze the production of superoxide anion and hydroxyl radical, reactive species that modify the structure and/or function of biomolecules. In ...