Buscar
Mostrando ítems 1-10 de 243
A case-control study of CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in colorectal cancer
(Funpec-editora, 2015-01-01)
Polymorphisms in genes encoding P450 cytochrome enzymes may increase the risk of sporadic colorectal cancer (SCRC). Here we investigated the association between SCRC and CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in a ...
Genetic polymorphisms of CYP2D6, CYP1A1 and CYP2E1 in the South-Amerindian population of Chile
(LIPPINCOTT WILLIAMS & WILKINS, 1998)
Polymorphisms of cytochrome P450 genes show pronounced interethnic variation and have not been previously studied in the South-Amerindian population, which probably has an Asian origin. Therefore, a similar distribution ...
CYP1A1 , CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms
(2016-12-07)
AIM: To investigate the contribution of polymorphisms in the CYP1A1 , CYP2E1 and EPHX1 genes on sporadic colorectal cancer (SCRC) risk. Methods: Six hundred forty-one individuals (227 patients with SCRC and 400 controls) ...
In vitro enantioselective inhibition of the main human CYP450 enzymes involved in drug metabolism by the chiral pesticide tebuconazole
(2021-10-15)
Tebuconazole (TEB) is a chiral triazole fungicide worldwide employed to control plant pathogens and preserve wood. People can be exposed to TEB either through diet and occupational contamination. This work investigates the ...
Cytochrome P450 2C19 poor metabolizer phenotype in treatment resistant depression: Treatment and diagnostic implications
(Frontiers Media, 2019)
Background: Pharmacogenomic testing, specifically for pharmacokinetic (PK) and pharmacodynamic (PD) genetic variation, may contribute to a better understanding of baseline genetic differences in patients seeking treatment ...
Risk assessment of the chiral pesticide fenamiphos in a human model: Cytochrome P450 phenotyping and inhibition studies
(2020-12-01)
Fenamiphos (FS) is a chiral organophosphate pesticide that is used to control nematodes in several crops. Enantioselective differences may be observed in FS activity, bioaccumulation, metabolism, and toxicity. Humans may ...
The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo
(Dove Medical Press Ltd., 2018)