Buscar
Mostrando ítems 1-10 de 719
Interplay between sequence, structure and linear motifs in the adenovirus E1A hub protein
(Academic Press Inc Elsevier Science, 2018-12)
E1A is the main transforming protein in mastadenoviruses. This work uses bioinformatics to extrapolate experimental knowledge from Human adenovirus serotype 5 and 12 E1A proteins to all known serotypes. A conserved domain ...
Relevance of CARC and CRAC Cholesterol-Recognition Motifs in the Nicotinic Acetylcholine Receptor and Other Membrane-Bound Receptors
(Elsevier Academic Press Inc, 2017-07)
Cholesterol is a ubiquitous neutral lipid, which finely tunes the activity of a wide range of membrane proteins, including neurotransmitter and hormone receptors and ion channels. Given the scarcity of available X-ray ...
Characterization and analysis of conserved motifs in a peroxisomal ATP-binding cassette transporter
(The American Society forBiochemistry and Molecular Biology, Inc., 1996)
The adrenoleukodystrophy protein (ALDP) and the 70-kDa peroxisomal membrane protein are half ATP-binding cassette (ABC) transporters in the human peroxisome membrane. Both are implicated in genetic disorders of peroxisome ...
An Evolutionary Marker of the Ribokinase Superfamily Is Responsible for Zinc-Mediated Regulation of Human Pyridoxal Kinase
(MDPI, 2020)
The ribokinase superfamily catalyzes the phosphorylation of a vast diversity of substrates, and its members are characterized by the conservation of a common structural fold along with highly conserved sequence motifs ...
GibbsCluster: unsupervised clustering and alignment of peptide sequences
(Oxford University Press, 2017-04)
Receptor interactions with short linear peptide fragments (ligands) are at the base of many biological signaling processes. Conserved and information-rich amino acid patterns, commonly called sequence motifs, shape and ...
Variability of the conserved V3 loop tip motif in HIV-1 subtype B isolates collected from Brazilian and French patients
(Sociedade Brasileira de Microbiologia, 2010-10-01)
The diversity of the V3 loop tip motif sequences of HIV-1 subtype B was analyzed in patients from Botucatu (Brazil) and Montpellier (France). Overall, 37 tetrameric tip motifs were identified, 28 and 17 of them being ...
Variability of the conserved V3 loop tip motif in HIV-1 subtype B isolates collected from Brazilian and French patients
(Sociedade Brasileira de Microbiologia, 2010-10-01)
The diversity of the V3 loop tip motif sequences of HIV-1 subtype B was analyzed in patients from Botucatu (Brazil) and Montpellier (France). Overall, 37 tetrameric tip motifs were identified, 28 and 17 of them being ...
Identificação de motivos conservados e prospecção de marcadores EST-SSR em genes responsáveis pela homeostase de metais pesados em plantas
(Universidade Federal do Pampa, 2016)
Dissecting the functional roles of the conserved nxxe and hxe motifs of the adp-dependent glucokinase from thermococcus litoralis
(2015)
The activity of the ADP-dependent glucokinase from Thermococcus litoralis (TIGK) relies on the highly conserved motifs NXXE (i.e. Asn-Xaa-Xaa-Glu) and HXE (i.e. His-Xaa-Glu). Site-directed mutagenesis of residues Glu279 ...
A lipocalin sequence signature modulates cell survival
(ELSEVIER SCIENCE BV, 2010)
Lipocalins are beta-barrel proteins, which share three conserved motifs in their amino acid sequence. In this study, we identified by a peptide mapping approach, a seven-amino acid sequence related to one of these motifs ...