Articulo
Dissecting the functional roles of the conserved nxxe and hxe motifs of the adp-dependent glucokinase from thermococcus litoralis
Fecha
2015Registro en:
1150460
WOS:000364604900009
Institución
Resumen
The activity of the ADP-dependent glucokinase from Thermococcus litoralis (TIGK) relies on the highly conserved motifs NXXE (i.e. Asn-Xaa-Xaa-Glu) and HXE (i.e. His-Xaa-Glu). Site-directed mutagenesis of residues Glu279 (11XE) and Glu308 (NXXE) leads to e