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Increase in distal airway mucus-producing Clara cells during primary Pneumocystis infection
(2018)
Airway Clara cells exhibit plasticity and may differentiate into goblet cells that
secrete mucus under different stimuli. Mucus originating in transformed Clara
cells along distal and alveolar duct airways that normally ...
Restoration of the normal Clara cell phenotype after chronic allergic inflammation
(Wiley Blackwell Publishing, Inc, 2013-12)
Bronchiolar Clara cells play a critical role in lung homoeostasis. The main goal of this study was to evaluate the effects of chronic allergy on these cells and the efficacy of budesonide (BUD) and montelukast (MK) in ...
Notch signaling controls the balance of ciliated and secretory cell fates in developing airways
(COMPANY OF BIOLOGISTS LTD, 2009)
Although there is accumulated evidence of a role for Notch in the developing lung, it is still unclear how disruption of Notch signaling affects lung progenitor cell fate and differentiation events in the airway epithelium. ...
Anteroposterior variation of the cell types in the interrenal gland of the male toad Rhinella arenarum (Amphibia, Anura)
(Wiley-liss, Div John Wiley & Sons Inc, 2013-03)
The interrenal gland of anurans synthesizes the steroids aldosterone and corticosterone, but it is unknown whether these hormones are synthesized by the same cell type. In this work, we aim to elucidate whether there are ...
Differential mechanisms of action are involved in chlorpyrifos effects in estrogen-dependent or -independent breast cancer cells exposed to low or high concentrations of the pesticide
(Elsevier Ireland, 2012-09)
It has reported that many environmental compounds may display estrogenic actions and these findings led to researchers to associate breast cancer risk with the use of some pesticides. The aim of this work was to investigate ...
Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells
(Frontiers Research Foundation, 2018-05)
Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune response and have been used since decades to treat various inflammatory and autoimmune disorders. Fine-tuning the glucocorticoid receptor ...
Development of a cell line from Echinococcus granulosus germinal layer
(Elsevier Science, 2013-07)
In vitro culture of parasitic helminths provides an important tool to study cell regeneration and physiology, as well as for molecular biology and genetic engineering studies. In the present study, we established in vitro ...
Avaliação de candidatos a marcadores moleculares envolvidos no carcinoma renal de células claras
(Universidade Estadual Paulista (Unesp), 2009-02-18)
O tumor renal é a mais letal das doenças urológicas. É uma doença histologicamente heterogênea, sendo o carcinoma renal de células claras o subtipo histológico mais comum. Embora a nefrectomia e imunoterapia sejam tratamentos ...
Avaliação de candidatos a marcadores moleculares envolvidos no carcinoma renal de células claras
(Universidade Estadual Paulista (Unesp), 2009-02-18)
O tumor renal é a mais letal das doenças urológicas. É uma doença histologicamente heterogênea, sendo o carcinoma renal de células claras o subtipo histológico mais comum. Embora a nefrectomia e imunoterapia sejam tratamentos ...
Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways
(Public Library of Science, 2019)
Clara cells are the main airway secretory cells able to regenerate epithelium in the distal airways through transdifferentiating into goblet cells, a process under negative regulation of the Notch pathway. Pneumocystis is ...