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Enantioseparation of pesticides: A critical review
(2020-01-01)
The potential of chiral pesticides to exhibit stereoselective behavior in regards to activity, toxicity, degradation, bioaccumulation, and/or metabolism has inspired numerous studies, e.g., several works have investigated ...
Semipreparative enantioseparation of methamidophos by HPLC-UV and preliminary in vitro study of butyrylcholinesterase inhibition
(Wiley-Blackwell, 2012-02-01)
Many chiral pesticides are introduced into the environment as racemates, although their pesticidal activity is usually the result of preferential reactivity of only one enantiomer, while the other enantiomer may have toxic ...
In vitro-in vivo correlation of the chiral pesticide prothioconazole after interaction with human CYP450 enzymes
(2022-05-01)
Growing human demand for food has culminated in increased use of pesticides worldwide. Prothioconazole (PTC), a profungicide, is bioactivated by metabolic PTC oxidation to prothioconazole-desthio (D-PTC). Here, the in vitro ...
Semipreparative enantioseparation of methamidophos by HPLC-UV and preliminary in vitro study of butyrylcholinesterase inhibition
(Wiley-Blackwell, 2012-02-01)
Many chiral pesticides are introduced into the environment as racemates, although their pesticidal activity is usually the result of preferential reactivity of only one enantiomer, while the other enantiomer may have toxic ...
Enantioseparation of the racemates of a number of pesticides on a silica-based column with immobilized amylose tris(3-chloro-5-methylphenylcarbamate)
(Elsevier Science, 2019-09)
We report here the results from studies on the high-performance liquid chromatographic HPLC enantioresolution of thirty different types of pesticides on the chiral silica-based column with immobilized amylose tris(3-chlo ...
Enantioseparation of polar pesticides on chiral capillary columns based on permethyl-β-cyclodextrin in matrices of different polarities
(Elsevier Science, 2018-07)
This work describes the influence of different achiral polymers used to dissolve permethyl-β-cyclodextrin (PM-β-CD) on the gas chromatographic enantioresolution of racemic mixtures of polar pesticides (mecoprop, dichlorprop, ...
Chiral separation of several pesticides on an immobilized amylose tris(3-chloro-5-methylphenylcarbamate) column under polar-organic conditions: influence of mobile phase and temperature on enantioselectivity
(Elsevier, 2020-08)
In this work, the use of different solvents and temperatures was explored, aiming to evaluate their influence on the enantioseparation of pesticides by HPLC in polar-organic conditions, employing a column containing ...
In vitro inhibition of human CYP2D6 by the chiral pesticide fipronil and its metabolite fipronil sulfone: Prediction of pesticide-drug interactions
(2019-10-01)
Fipronil is a chiral insecticide employed worldwide in crops, control of public hygiene and control of veterinary pests. Humans can be exposed to fipronil through occupational, food, and environmental contamination. ...
Comparative in vitro study of the inhibition of human and hen esterases by methamidophos enantiomers
(Elsevier B.V., 2012-02-26)
The current Organisation for Economic Co-operation and Development (OECD) guidelines for evaluating organophosphorus-induced delayed neuropathy (OPIDN) require the observation of dosed animals over several days and the ...