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Development and validation of a Novel ELISA for the specific detection of antibodies against Mycobacterium avium subspecies paratuberculosis based on a chimeric polyprotein
(Hindawi Publishing Corporation, 2021-12)
Bovine paratuberculosis (PTB) is caused by Mycobacterium avium subsp. paratuberculosis (MAP). The optimization of detection tests specific for MAP is crucial to improve PTB control. In this work, we aimed to develop and ...
Prototype of an ELISA on the HRP system using a chimeric polyprotein for the diagnosis of chronic Trypanosoma cruzi infection
(Fiocruz/Instituto de Tecnologia em Imunobiológicos, 2022)
Chimeric vlps based on hiv-1 gag and a fusion rabies glycoprotein induce specific antibodies against rabies and foot-and-mouth disease virus
(Multidisciplinary Digital Publishing Institute, 2021-03)
Foot and mouth disease is a livestock acute disease, causing economic losses in affected areas. Currently, control of this disease is performed by mandatory vaccination campaigns using inactivated viral vaccines. In this ...
Lentiviral Gag assembly analyzed through the functional characterization of chimeric simian immunodeficiency viruses expressing different domains of the feline immunodeficiency virus capsid protein e114299
(Public Library of Science, 2014-12)
To gain insight into the functional relationship between the capsid (CA) domains of the Gag polyproteins of simian and feline immunodeficiency viruses (SIV and FIV, respectively), we constructed chimeric SIVs in which the ...
Analysis of the functional compatibility of SIV capsid sequences in the context of the FIV gag precursor
(Public Library of Science, 2017-05)
The formation of immature lentiviral particles is dependent on the multimerization of the Gag polyprotein at the plasma membrane of the infected cells. One key player in the virus assembly process is the capsid (CA) domain ...
Polymorphisms in p1-p6/p6* of HIV Type 1 Can Delay Protease Autoprocessing and Increase Drug Susceptibility
(Mary Ann Liebert, 2003-09)
Maturation of infectious human immunodeficiency virus type 1 (HIV-1) particles requires proteolytic cleavage of structural polyproteins by viral protease. Inhibition of protease is a powerful tool for the treatment of HIV ...