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Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines
(Elsevier, 2015)
A series of original 2-phenyl-3-(pyridin-4-yl)imidazo[1,2-a]pyrazines and the 3-iodo precursors, bearing a polar moiety at the C-8 position, was synthesized and evaluated for their antileishmanial activities. Two derivatives ...
Sustainable synthesis of ciclopentene derivatives through multicomponent reactions in continuous flow regime
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2020-03-25)
Sustainable chemistry has gained relevance in recent years, not only in the fine chemical industry, but also in organic synthesis. This new conception of chemistry allows the development of environmentally friendly processes, ...
Green by Design: Convergent Synthesis, Computational Analyses, and Activity Evaluation of New FXa Inhibitors Bearing Peptide Triazole Linking Units
(2022)
Green chemistry implementation has led to promising results in waste reduction in the pharmaceutical industry. However, the early sustainable development of pharmaceutically active compounds and ingredients remains a ...
Flow chemistry applied to hazardous reactions, and fluorophores synthesis with photophysics studies
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2020-02-20)
Two distinct cases of continuous flow conditions applied to dangerous reactions are described. The first example is the continuous photooxygenation of a series of dienes that produces endoperoxides and / which are potentially ...
Coupling biocatalysis and click chemistry: one-pot two-step convergent synthesis of enantioenriched 1,2,3-triazole-derived diols
(Royal Society of Chemistry, 2013-02)
A fully convergent one-pot two-step synthesis of different chiral 1,2,3-triazole-derived diols in high yields and excellent enantio- and diastereoselectivities has been achieved under very mild conditions in aqueous medium ...
The Nobel Prize In Chemistry 2016: Molecular Machines
(Soc Brasileira QuimicaSão Paulo, 2017)
Total synthesis of annofolin
(Taylor & Francis, 1999)
The synthesis of annofolin (1), an alkaloid isolated from Annona hayesii in small amounts, by a phase-transfer catalytic reduction-methylation of cleistopholin (2) is reported, together with the preparation of its derivatives ...