info:eu-repo/semantics/article
Coupling biocatalysis and click chemistry: one-pot two-step convergent synthesis of enantioenriched 1,2,3-triazole-derived diols
Fecha
2013-02Registro en:
Cuetos, Aníbal; Bisogno, Fabricio Román; Lavandera, Iván; Gotor, Vicente; Coupling biocatalysis and click chemistry: one-pot two-step convergent synthesis of enantioenriched 1,2,3-triazole-derived diols; Royal Society of Chemistry; Chemical Communications; 49; 26; 2-2013; 2625-2627
1359-7345
CONICET Digital
CONICET
Autor
Cuetos, Aníbal
Bisogno, Fabricio Román
Lavandera, Iván
Gotor, Vicente
Resumen
A fully convergent one-pot two-step synthesis of different chiral 1,2,3-triazole-derived diols in high yields and excellent enantio- and diastereoselectivities has been achieved under very mild conditions in aqueous medium by combining a single alcohol dehydrogenase (ADH) with a Cu-catalysed ‘click’ reaction.