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Unexpected inhibitory cascade in the molariforms of sloths (Folivora, Xenarthra): a case study in xenarthrans honouring Gerhard Storch’s open-mindedness
(Národní muzeum, 2020)
The inhibitory cascade (IC) represents a developmental model that explains the evolution of molar relative sizes, originally described in rodents but later validated in several mammalian groups. The IC comprises signalling ...
Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2
(2020)
Abstract
Background
The intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity ...
Activation of Signaling Lymphocytic Activation Molecule triggers a signaling cascade that enhances Th1 responses in human intracellular infection
(American Association of Immunologists, 2004-09)
T cell production of IFN- contributes to host defense against infection by intracellular pathogens, including mycobacteria. Lepromatous leprosy, the disseminated form of infection caused by Mycobacterium leprae, is ...
Charge regulation phenomenon predicted from the modeling of polypeptide electrophoretic mobilities as a relevant mechanism of amyloid-beta peptide oligomerization
(Wiley VCH Verlag, 2016-03)
Electrophoretic mobilities of amyloid-beta (1-40) and (1-42) peptides and their aggregates are modeled to study the amyloidogenic pathway associated with Alzheimer´s Disease. The near molecule pH generated by the intraparticle ...
Pericyclic Cascade toward Isochromenes: Application to the Synthesis of Alkaloid Benzosimuline
(American Chemical Society, 2016-09)
The synthesis of biologically active alkaloid benzosimuline, isolated from the shrub Zanthoxylum simulans, is reported. Key transformation involves an oxa-6π electrocyclic ring-opening/hetero-Diels-Alder pericyclic cascade. ...
Unravelling ties in the nitrogen network: Polyamines and nitric oxide emerging as essential players in signalling roadway
(Wiley Blackwell Publishing, Inc, 2020-09)
Nitrogen (N) is a central mineral nutrient essential for plant development and growth. It is usually scarcely found in soils, so the knowledge of the overall plant N metabolism deserves substantial attention. Polyamines ...
Spatially resolved optical emission study of sputtering in reactive plasmas
(Amer Inst PhysicsWoodburyEUA, 1998)
Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2
(BMC, 2020)
BackgroundThe intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity is increased. Besides, in preclinical models of diabetes, ...