Artículos de revistas
Pericyclic Cascade toward Isochromenes: Application to the Synthesis of Alkaloid Benzosimuline
Fecha
2016-09Registro en:
Riveira, Martín Jorge; la Venia, Agustina; Mischne, Mirta Paulina; Pericyclic Cascade toward Isochromenes: Application to the Synthesis of Alkaloid Benzosimuline; American Chemical Society; Journal of Organic Chemistry; 81; 17; 9-2016; 7977-7983
0022-3263
CONICET Digital
CONICET
Autor
Riveira, Martín Jorge
la Venia, Agustina
Mischne, Mirta Paulina
Resumen
The synthesis of biologically active alkaloid benzosimuline, isolated from the shrub Zanthoxylum simulans, is reported. Key transformation involves an oxa-6π electrocyclic ring-opening/hetero-Diels-Alder pericyclic cascade. Although the last aromatization step proved to be cumbersome, this work unfolds a unique route to access interesting molecules from simple precursors.