Buscar
Mostrando ítems 1-10 de 279
TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways
(2013)
Ischemia/reperfusion injury is a major cause of myocardial death. In the heart, cardiac fibroblasts play a
critical role in healing post myocardial infarction. TGF-β1 has shown cardioprotective effects in cardiac damage; ...
IGF-1 modulation of rat cardiac fibroblast behavior and gene expression is age-dependent
(TAYLOR & FRANCIS LTD, 2003-05)
The collagenous extracellular matrix (ECM) forms a stress-tolerant network that is essential for proper function of the vertebrate heart. Profound changes have been detected in the interstitial ECM concurrent with developmental ...
Expression and function of toll-like receptor 4 and inflammasomes in cardiac fibroblasts and myofibroblasts: IL-1β synthesis, secretion, and degradation
(Elsevier Ltd, 2016)
© 2016 Elsevier Ltd. Cardiac inflammation can be produced by pathogen-associated molecular patterns (PAMPs), from parasitic, bacterial or viral origin; or by danger-associated molecular patterns (DAMPs), released from dead ...
Cardiac fibroblasts as sentinel cells in cardiac tissue: Receptors, signaling pathways and cellular functions
(Elsevier, 2015)
Cardiac fibroblasts (CF) not only modulate extracellular matrix (ECM) proteins homeostasis, but also respond to chemical and mechanical signals. CF express a variety of receptors through which they modulate the proliferation/cell ...
β2-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation
(2010)
Autophagy is a physiological degradative process key to cell survival during nutrient deprivation, cell differentiation and development. It plays a major role in the turnover of damaged macromolecules and organelles, and ...
Cardiac fibroblast cytokine profiles induced by proinflammatory or profibrotic stimuli promote monocyte recruitment and modulate macrophage M1/M2 balance in vitro
(Academic Press, 2016)
© 2016 Elsevier Ltd Macrophage polarization plays an essential role in cardiac remodeling after injury, evolving from an initial accumulation of proinflammatory M1 macrophages to a greater balance of anti-inflammatory M2 ...
FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation
(Elsevier, 2016)
© 2015 Elsevier B.V. Cardiac fibroblast differentiation to myofibroblast is a crucial process in the development of cardiac fibrosis and is tightly dependent on transforming growth factor beta-1 (TGF-β1). The transcription ...
Expression and function of TLR4- induced B1R bradykinin receptor on cardiac fibroblasts
(Academic Press Inc., 2018)
© 2018 Elsevier Inc. Cardiac fibroblasts (CF) are key cells for maintaining extracellular matrix (ECM) protein homeostasis in the heart, and for cardiac repair through CF-to-cardiac myofibroblast (CMF) differentiation. ...
Heparan sulfate potentiates leukocyte adhesion on cardiac fibroblast by enhancing Vcam-1 and Icam-1 expression
(Elsevier, 2018)
Cardiac fibroblasts (CF) act as sentinel cells responding to chemokines, cytokines and growth factors released in cardiac tissue in cardiac injury events, such as myocardial infarction (MI). Cardiac injury involves the ...