Article
Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins
Registro en:
COELHO, Laura Lacerda; et al. Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblastmyofibroblast transition and increase in expression of extracellular matrix proteins. Parasites & Vectors, v.11, n.72, 11p, 2018.
1756-3305
10.1186/s13071-018-2614-1
Autor
Coelho, Laura Lacerda
Pereira, Isabela Resende
Pereira, Mirian Claudia de Souza
Mesquita, Liliane
Lannes-Vieira, Joseli
Adesse, Daniel
Garzoni, Luciana Ribeiro
Resumen
Cardiac fibrosis is a consequence of chronic chagasic cardiomyopathy (CCC). In other cardiovascular diseases, the protagonist role of fibroblasts in cardiac fibrosis is well established. However, the role of cardiac fibroblasts (CFs) in fibrosis during the CCC is not clear. Here, our aim was to investigate the effect of Trypanosoma cruzi, the etiological agent of Chagas disease on CFs activation.