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Activation of Caenorhabditis elegans Levamisole-Sensitive and Mammalian Nicotinic Receptors by the Antiparasitic Bephenium
(American Society for Pharmacology and Experimental Therapeutics, 2018-11)
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels involved in neuromuscular transmission. In nematodes, muscle nAChRs are targets of antiparasitic drugs. Bephenium is an anthelmintic compound whose ...
Transgenerational diapause as an avoidance strategy against bacterial pathogens in caenorhabditis elegans
(American Society Microbiology, 2017)
The dynamic response of organisms exposed to environmental pathogens determines their survival or demise, and the outcome of this interaction depends on the host's susceptibility and pathogen-dependent virulence factors. ...
In vitro and alternative animal models to evaluate the biocompatibility of natural latex-calcium phosphate-based polymer
(2022-01-01)
The number of mammalian animals killed for research purposes has increased significantly in recent years. For this reason, several alternative animal models have been widely used. In this study, two phases of calcium ...
Endocannabinoids in Caenorhabditis elegans are essential for the mobilization of cholesterol from internal reserves
(Nature Publishing Group, 2018-12)
Proper cholesterol transport is crucial for the functionality of cells. In C. elegans, certain cholesterol derivatives called dafachronic acids (DAs) govern the entry into diapause. In their absence, worms form a developmentally ...
In vitro and in vivo effect of peptides derived from 14-3-3 Paracoccidioides spp. Protein
(2021-01-01)
Background: Paracoccidioidomycosis (PCM) is a chronic disease that causes sequelae and requires prolonged treatment; therefore, new therapeutic approaches are necessary. In view of this, three peptides from Paracoccidioides ...
Avaliação do efeito anti-helmíntico do extrato bruto da planta Tocoyena bullata no modelo Caenorhabditis elegans
(Universidade Federal do Rio de JaneiroBrasilInstituto de Ciências FarmacêuticasUFRJ, 2023)
Antifungal Efficacy during Candida krusei Infection in Non-Conventional Models Correlates with the Yeast In Vitro Susceptibility Profile
(2013-03-28)
The incidence of opportunistic fungal infections has increased in recent decades due to the growing proportion of immunocompromised patients in our society. Candida krusei has been described as a causative agent of ...
Antifungal Efficacy during Candida krusei Infection in Non-Conventional Models Correlates with the Yeast In Vitro Susceptibility Profile
(2013-03-28)
The incidence of opportunistic fungal infections has increased in recent decades due to the growing proportion of immunocompromised patients in our society. Candida krusei has been described as a causative agent of ...
Synthesis and Evaluation of the Antifungal and Toxicological Activity of Nitrofuran Derivatives
(2022-03-01)
Fungal diseases affect more than 1 billion people worldwide. The constant global changes, the advent of new pandemics, and chronic diseases favor the diffusion of fungal pathogens such as Candida, Cryptococcus, Aspergillus, ...
Avaliação do efeito do extrato bruto da planta Stachytarpheta schottiana na sobrevivência e morfologia de Caenorhabditis elegans
(Universidade Federal do Rio de JaneiroBrasilInstituto de Ciências FarmacêuticasUFRJ, 2023)