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Genetic polymorphisms of CYP2D6, CYP1A1 and CYP2E1 in the South-Amerindian population of Chile

Munoz, S; Vollrath, V; Vallejos, MP; Miquel, JF; Covarrubias, C; Raddatz, A; Chianale, T (LIPPINCOTT WILLIAMS & WILKINS, 1998)

Polymorphisms of cytochrome P450 genes show pronounced interethnic variation and have not been previously studied in the South-Amerindian population, which probably has an Asian origin. Therefore, a similar distribution ...

CYP1A1 and CYP2E1 polymorphism frequencies in a large Brazilian population

Coura, Renata dos; Marques, Christiane de Fátima Silva; Koifman, Rosalina J.; Koifman, Sergio; Cabello, Pedro Hernan; Hatagima, Ana (Sociedade Brasileira de Genética, 2018)

Interethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 Ibero- and native americans: RIBEF-CEIBA Consortium Report on population pharmacogenomics

Naranjo, María Eugenia G.; Rodrigues Soares, Fernanda; Peñas Lledó, Eva M.; Tarazona Santos, Eduardo; Fariñas, Humberto; Rodeiro, Idania; Terán, Enrique; Grazina, Manuela; Moya, Graciela E.; López López, Marisol; Sarmiento, Alba P.; Calzadilla, Luis R.; Ramírez Roa, Ronald; Ortiz López, Rocío; Estévez Carrizo, Francisco E.; Sosa Macías, Martha; Barrantes, Ramiro; LLerena, Adrián (Mary Ann Liebert, 2022)

Niveles de expresión de citocromos P450 (CYP6AA7, CYP4C52v1, CYP6BY3, CYP9J34, CYP9M10, CYP9J40 y CYP9AL1) determinados por RT-qPCR en larvas de Culex quinquefasciatus expuestas a diversos insecticidas.

Rodríguez Sánchez, Iram Pablo (2015)

Impact of fraction unbound, CYP3A, and CYP2D6 in vivo activities, and other potential covariates to the clearance of tramadol enantiomers in patients with neuropathic pain

Universidade Estadual Paulista (Unesp); Universidade de São Paulo (USP) (Wiley-Blackwell, 2016-04-01)

The pharmacokinetics of tramadol is characterized by a large interindividual variability, which is partially attributed to polymorphic CYP2D6 metabolism. The contribution of CYP3A, CYP2B6, fraction unbound, and other ...

Avaliação de polimorfismos nos genes CYP1A1, CYP2D6 e CYP19 em uma amostra de pacientes com cancer de mama esporadicoEvaluation of polymorphism in the genes CYP1A1, CYP2D6 and CYP19 in patients with cancer of sporadic breast

Rueda, Lidiane Camila, 1982- ([s.n.], 2008)

Statin regulation of CYP3A4 and CYP3A5 expression

WILLRICH, Maria Alice Vieira; HIRATA, Mario Hiroyuki; HIRATA, Rosario Dominguez Crespo (FUTURE MEDICINE LTD, 2009)

CYP3A4 and CYP3A5 are cytochrome P450 enzymes that are highly expressed in the liver and gut and metabolize endogenous compounds and xenobiotics. Statins are cholesterol-lowering drugs that are extensively metabolized by ...

Impact of inhalational exposure to ethanol fuel on the pharmacokinetics of verapamil, ibuprofen and fluoxetine as in vivo probe drugs for CYP3A, CYP2C and CYP2D in rats

Universidade de São Paulo (USP); Universidade Estadual Paulista (Unesp) (Elsevier B.V., 2015-10-01)

Occupational toxicology and clinical pharmacology integration will be useful to understand potential exposure-drug interaction and to shape risk assessment strategies in order to improve occupational health. The aim of the ...

A case-control study of CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in colorectal cancer

Universidade Estadual Paulista (Unesp); Universidade de São Paulo (USP) (Funpec-editora, 2015-01-01)

Polymorphisms in genes encoding P450 cytochrome enzymes may increase the risk of sporadic colorectal cancer (SCRC). Here we investigated the association between SCRC and CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in a ...

Extraadrenal 21-Hydroxylation by CYP2C19 and CYP3A4: Effect on 21-Hydroxylase Deficiency

GOMES, Larissa G.; HUANG, Ningwu; AGRAWAL, Vishal; MENDONCA, Berenice B.; BACHEGA, Tania A. S. S.; MILLER, Walter L. (ENDOCRINE SOC, 2009)

Context: 21-Hydroxylase deficiency (21OHD) is caused by CYP21A2 gene mutations disrupting the adrenal 21-hydroxylase, P450c21. CYP21A2 mutations generally correlate well with the 21OHD phenotype, but some children with ...

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