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Efeitos da sinalização via CREB sobre a sobrevivência e diferenciação neuronal
(Universidade Federal do Rio Grande do NorteBRUFRNPrograma de Pós-Graduação em NeurocienciasNeurobiologia Celular e Molecular; Neurobiologia de Sistemas e Cognição; Neurocomputação Neuroengen, 2012-12-21)
The cortical development requires a precise process of proliferation, migration, survival and differentiation of newly formed neurons to finally achieve the development of a functional network. Different kinases, such as ...
Oxidative stress-induced CREB upregulation promotes DNA damage repair prior to neuronal cell death protection
(Springer, 2017-01)
cAMP response element-binding (CREB) protein is a cellular transcription factor that mediates responses to different physiological and pathological signals. Using a model of human neuronal cells we demonstrate herein, that ...
Stress induces behavioral sensitization, increases nicotine-seeking behavior and leads to a decrease of CREB in the nucleus accumbens
(Pergamon-Elsevier B.V. Ltd, 2012-05-01)
Experimental evidence shows that exposure to stress engenders behavioral sensitization and increases drug-seeking and leads to intense drug taking. However the molecular mechanisms involved in these processes is not well ...
Stress induces behavioral sensitization, increases nicotine-seeking behavior and leads to a decrease of CREB in the nucleus accumbens
(Pergamon-Elsevier B.V. Ltd, 2014)
Influence of the dopaminergic system, CREB, and transcription factor-B on cocaine neurotoxicity
(Associação Brasileira de Divulgação Científica (ABRADIC), 2013-11-01)
Cocaine is a widely used drug and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newborns have been demonstrated to be due to the toxic effects of cocaine during fetal development. ...
IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005-11-04)
Hyperosmotic stress stimulates a rapid and pronounced apoptosis in cardiac myocytes which is attenuated by insulin-like growth factor-1 (IGF-1). Because in these cells IGF-1 induces intracellular Ca2+ increase, we assessed ...
The CREB-binding protein (CBP) cooperates with the serum response factor for transactivation of the c-fos serum response element
The serum response element is one of the major promoter elements of the immediate early response to extracellular signals. The serum response element includes two main binding sites for proteins: the Ets box, which binds ...
Influence of the dopaminergic system, CREB, and transcription factor-B on cocaine neurotoxicity
(Associação Brasileira de Divulgação Científica (ABRADIC), 2014)