A criação de camundongos transgênicos representou um enorme avanço para a ciência. O sistema Cre-Lox, é um sistema de edição genética através da recombinação de DNA sítio-específica. A enzima Cre recombinase reconhece ...

The genetic manipulation of Trypanosoma cruzi continues to be a challenge, mainly due to the lack of available and efficient molecular tools. The CRE-lox recombination system is a site-specific recombinase technology, ...

Genetic mouse models based on the Cre-loxP system have been extensively used to explore the influence of specific gene deletions on different aspects of behavioral neurobiology. However, the interpretation of the effects ...

To introduce restricted DNA recombination events into catecholaminergic neurons using the Cre/loxP technology, we generated transgenic mice carrying the Cre recombinase gene driven by a 9 kb rat tyrosine hydroxylase (TH) ...

To study the impact of regulatory sequences from Cowpea mosaic virus (CPMV) on Cre-mediated recombination rates, the cre gene was flanked by the 5′ non-translated and 3′ non-translated regions of CPMV. This cre configuration ...

Os genes supressores de tumor (GSTs) são genes que codificam proteínas supressoras tumorais (PSTs), essas proteínas quando expressas agem através de diferentes mecanismos no controle do crescimento e proliferação celular ...