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Crosstalk of BMP-4 and RA signaling pathways on Pomc gene regulation in corticotrophs
(BioScientifica, 2019-10)
Retinoic acid (RA), an active metabolite of Vitamin A, and bone morphogenetic protein 4 (BMP-4) pathways control the transcription of pro-opiomelanocortin (Pomc), the precursor of ACTH. We describe a novel mechanism by ...
Immunohistochemical analysis of the hypothalamic-pituitary-adrenal axis in dogs: Sex-linked and seasonal variation
(Elsevier, 2016-02)
This study evaluated sexual dimorphism and seasonal variations in corticotrophs and adrenal zona fasciculata in dogs, as well as the expression of oestrogen receptor alpha (ERα). An immunohistochemical analysis was conducted ...
Bone Morphogenetic Protein-4 Inhibits Corticotroph Tumor Cells: Involvement in the Retinoic Acid Inhibitory Action
(Endocrine Society, 2006-01)
The molecular mechanisms governing the pathogenesis of ACTH-secreting pituitary adenomas are still obscure. Furthermore, the pharmacological treatment of these tumors is limited. In this study, we report that bone morphogenetic ...
New Insights in Cushing Disease Treatment With Focus on a Derivative of Vitamin A
(Frontiers Research Foundation, 2018-05)
Cushing's disease (CD) is an endocrine disorder originated by a corticotroph tumor. It is linked with high mortality and morbidity due to chronic hypercortisolism. Treatment goals are to control cortisol excess and achieve ...
Plasma ACTH, α-MSH and cortisol variations in the dog during the oestrous cycle in different photoperiods
(Veterinary Research Inst, 2015-10)
The hypothalamic-pituitary-adrenal axis (HPA) is a complex system regulated by multiple factors.Sexual dimorphism of this axis has been described in different species under physiological conditions and it hasbeen proposed ...
Pituitary of non-pregnant and pregnant viscachas (Lagostomus maximus maximus): a comparative study by immunohistochemical and morphometric analysis
(Elsevier Gmbh, 2010-12)
The neuroendocrine hypothalamic-pituitary axis undergoes morphological and biochemical changes throughout gestation. In viscacha, pregnancy lasts approximately 154 days, and three stages can be described: early, mid- and ...
Estudio del área corticotropa del perro en relación al sexo y variaciones estacionales
(Universidad de Buenos Aires. Facultad de Ciencias Veterinarias, 2015)
Association between tumoral GH-releasing peptide receptor type 1a mRNA expression and in vivo response to GH-releasing peptide-6 in ACTH-dependent Cushing`s syndrome patients
(BIO SCIENTIFICA LTD, 2008)
Objective: GH secretagogues (GHS) produce exaggerated ACTH and cortisol responses in Cushing`s disease (CD) patients, attributable to their direct action on GH-releasing peptide receptor type la (GHSR-1a). However, there ...
Pituitary tumors: Cell type-specific roles for BMP-4
(Elsevier Ireland, 2010-09)
BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and ...