info:eu-repo/semantics/article
Pituitary tumors: Cell type-specific roles for BMP-4
Fecha
2010-09Registro en:
Labeur, Marta; Páez Pereda, Marcelo; Haedo, Mariana Raquel; Arzt, Eduardo Simon; Stalla, Günter K.; Pituitary tumors: Cell type-specific roles for BMP-4; Elsevier Ireland; Molecular and Cellular Endocrinology; 326; 1-2; 9-2010; 85-88
0303-7207
CONICET Digital
CONICET
Autor
Labeur, Marta
Páez Pereda, Marcelo
Haedo, Mariana Raquel
Arzt, Eduardo Simon
Stalla, Günter K.
Resumen
BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it inhibits ACTH production and cell proliferation of corticotrophs. In addition, BMP-4 increases GH secretion in rat pituitary tumor somatolactotroph GH3 cells and FSHβ subunit gene transcription in the murine gonadotroph cell line, LβT2. Therefore, BMP-4 has a differential role on different types of pituitary tumors: it promotes pituitary prolactinoma while it inhibits corticotroph pathogenesis in Cushing's disease. The modulation of BMP-4 also plays an important role in the therapeutic mechanism of action of bromocriptine, somatostatin analogs and retinoic acid.