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Tumor-stroma interaction increases CD147 expression in neoplastic B lymphocytes in chronic lymphocytic leukemia
(Academic Press Inc Elsevier Science, 2020-05)
Chronic lymphocytic leukemia (CLL) microenvironment plays a critical role in disease pathogenesis. Matrix metalloproteinases (MMPs) are involved in CLL-B cell migration and survival. CD147 is associated with MMPs production ...
Non-malignant leukocytes delay spontaneous B-CLL cell apoptosis
(Nature Publishing Group, 2001-12)
Malignant B cells from chronic lymphocytic leukemia (B-CLL) patients have a long survival in vivo, although, in culture, they spontaneously die by apoptosis. Here, we analyzed the capacity of accessory leukocytes to modulate ...
LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL
(2018)
Lipoprotein lipase (LPL) mRNA expression in chronic lymphocytic leukaemia (CLL) is associated with an unmutated immunoglobulin profile and poor clinical outcome. We evaluated the subcellular localization of LPL protein in ...
Signaling capacity of FcγRII isoforms in B-CLL cells
(Pergamon-Elsevier Science Ltd, 2005-11)
Two main isoforms of Fcγ receptor II (CD32) have been described in humans: activatory FcγRIIA and inhibitory FcγRIIB. We have previously reported that B cells from a subset of chronic lymphocytic leukemia (B-CLL) patients ...
Immune complexes and apoptosis in B-cell chronic lymphocytic leukemia
(Taylor & Francis, 2002-02)
The progressive accumulation of B-cell chronic lymphocytic leukemia (B-CLL) cells in vivo is attributed to resistance to apoptosis, although this can be modulated in vitro by a variety of cellular and humoral factors ...
High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: Link with an activated microenvironment in CLL disease
(American Society of Hematology, 2010-06)
Interaction of chronic lymphocytic leukemia (CLL) B cells with tissue microenvironment has been suggested to favor disease progression by promoting malignant B-cell growth. Previous work has shown expression in peripheral ...
SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL
(AMER SOC HEMATOLOGY, 2008)
To identify novel genes involved in the molecular pathogenesis of chronic lymphocytic leukemia (CLL) we performed a serial analysis of gene expression (SAGE) in CLL cells, and compared this with healthy B cells (nCD19(+)). ...
AID overexpression leads to aggressive murine CLL and non-Ig mutations that mirror human neoplasms.
(American Society of Hematology, 2021-07)
Most cancers become more dangerous by the outgrowth of malignant subclones with additional DNA mutations that favor proliferation or survival. Using chronic lymphocytic leukemia (CLL), a disease exemplary of this process, ...
Lipoprotein lipase expression in unmutated CLL patients is the consequence of a demethylation process induced by the microenvironment
(Nature Publishing Group, 2013-03)
We have previously demonstrated that lipoprotein lipase (LPL) is associated to an unmutated immunoglobulin profile and clinical poor outcome in Chronic Lymphocytic Leukemia (CLL). Despite the usefulness of LPL for CLL ...
Ibrutinib therapy downregulates AID enzyme and proliferative fractions in chronic lymphocytic leukemia
(American Society of Hematology, 2019-05-13)
Activation-induced cytidine deaminase (AID) initiates somatic hypermutation and class switch recombination of the immunoglobulin genes. As a trade-off for its physiological function, AID also contributes to tumor development ...