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CKD-MBD: from the Pathogenesis to the Identification and Development of Potential Novel Therapeutic Targets
(2018-12-01)
Purpose of Review: Although we have seen tremendous advances in the comprehension of CKD-MBD pathophysiology during the last few years, this was not accompanied by a significant change in mortality rate and quality of life. ...
Advanced Glycation End Products (ages), Cardiovascular Disease And Ckd-mbd In Hemodialysis Patients
(OXFORD UNIV PRESSOXFORD, 2015)
High prevalence of biochemical disturbances of chronic kidney disease - mineral and bone disorders (CKD-MBD) in a nation-wide peritoneal dialysis cohort: are guideline goals too hard to achieve?
(2021-04-01)
INTRODUCTION: Chronic kidney disease - mineral and bone disorders (CKD-MBD) are common in dialysis patients. Definition of targets for calcium (Ca), phosphorus (P), parathormone (iPTH), and alkaline phosphatase (ALP) and ...
Early Control of PTH and FGF23 in Normophosphatemic CKD Patients: A New Target in CKD-MBD Therapy?
(AMER SOC NEPHROLOGY, 2010)
Background and objectives: Levels of parathyroid hormone (PTH) and the phosphaturic hormone FGF23, a fibroblast growth factor (FGF) family member, increase early in chronic kidney disease (CKD) before the occurrence of ...
Serum sclerostin is an independent predictor of mortality in hemodialysis patients
(BMC, 2014-12-02)
Background
Sclerostin (Scl) has recently emerged as a novel marker of bone remodeling and vascular calcification. However, whether high circulating Scl is also a risk factor for death is not well established. ...
Repression of osteocyte Wnt/beta-catenin signaling is an early event in the progression of renal osteodystrophy
(WILEY-BLACKWELLHOBOKEN, 2012)
Chronic kidney diseasemineral bone disorder (CKD-MBD) is defined by abnormalities in mineral and hormone metabolism, bone histomorphometric changes, and/or the presence of soft-tissue calcification. Emerging evidence ...
Enfermedad Renal Crónica y Urolitiasis en estudiantes de la FBCB, UNL. Evaluación de marcadores bioquímicos de CKD-Mineral Bone Disorder vs. función renal. Estudio del riesgo de urolitiasis vinculado a ingesta de sodio en alumnos sin antecedentes. 2020-23.
Enfermedad renal crónica (ERC) y urolitiasis (UL) son problemas relevantes de Salud Pública. Los estadios tempranos de ERC son generalmente asintomáticos y se definen por tasa de filtrado glomerular (TFG) normal o alta ...
Registro Brasileiro de Biópsias Ósseas (REBRABO): desenho, banco de dados e metodologia
(Sociedade Brasileira de Nefrologia, 2014-09-01)
Introduction: Mineral bone disorder (MBD) is a common condition in chronic kidney disease (CKD) patients and causes significant morbidity and mortality. Data involving prevalence of alterations in bone histological patterns, ...
Fibroblast Growth Factor 23 in Hemodialysis Patients: Effects of Phosphate Binder, Calcitriol and Calcium Concentration in the Dialysate
(Karger, 2011-01-01)
Background: Fibroblast growth factor 23 (FGF23) concentrations increase early in chronic kidney disease (CKD), and the influence of current CKD-mineral and bone disorder (MBD) therapies on serum FGF23 levels is still under ...