Artículos de revistas
Serum sclerostin is an independent predictor of mortality in hemodialysis patients
Fecha
2014-12-02Registro en:
BMC Nephrology. 2014 Dec 02;15(1):190
10.1186/1471-2369-15-190
Autor
Gonçalves, Flávia L C
Elias, Rosilene M
Reis, Luciene M. dos
Graciolli, Fabiana G
Zampieri, Fernando G
Oliveira, Rodrigo B
Jorgetti, Vanda
Moyses, Rosa M A
Institución
Resumen
Background
Sclerostin (Scl) has recently emerged as a novel marker of bone remodeling and vascular calcification. However, whether high circulating Scl is also a risk factor for death is not well established. The purpose of this study was to test whether serum Scl would be associated with mortality.
Methods
we measured serum Scl in a hemodialysis patients’ cohort, which was followed during a ten-year period. Competing risk regression models were applied, as during the follow-up, patients were exposed to both events kidney transplant and death.
Results
Ninety-one patients aged 42.3 ± 18.8 years (55% of male gender, 15% of diabetes) were included. During the follow-up, 32 patients underwent kidney transplant and 26 patients died. Non-survivals presented higher FGF23, higher Scl and lower creatinine. There was an association between all-cause mortality and higher Scl (HR = 2.2), higher age (HR = 1.04) and presence of diabetes (HR = 2.27), by competing risk analyses. Even including potential markers of mortality, as creatinine, FGF 23, and gender, Scl, age and diabetes remained significantly related to higher mortality.
Conclusion
Serum Scl is an independent predictor of mortality in dialysis patients. However, whether clinical interventions to modulate Scl would be able to improve these patients survival needs to be determined.