Reverse cholesterol transport (RCT) is key for cellular cholesterol homeostasis, involving cholesterol efflux from cells to circulating high density lipoproteins (HDL) via ABC transporters followed by HDL cholesterol uptake ...

After approximately 3 weeks in vitro, hippocampal neurons present many of the typical hallmarks accompanying neuronal aging in vivo, including accumulation of reactive oxygen species (ROS), lipofuscin granules, heterochromatic ...

The high density lipoprotein (HDL) receptor SR-BI (scavenger receptor class B type I) mediates the selective uptake of plasma HDL cholesterol by the liver and steroidogenic tissues. As a consequence, SR-BI can influence ...

Cholesterol is an important molecule; it is necessary for the biosynthesis of steroidal hormones, bile salts and to maintain the stability of biological membranes in animal cells. However, its excess is negative and is ...

Arenavirus morphogenesis and budding occurs at cellular plasma membrane;however, the nature of membrane assembly sites remains poorly understood. In this study we examined the effect of different cholesterol-lowering ...

The adult brain exhibit a characteristic cholesterol homeostasis, with low synthesis rate and active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme Cytochrome P450 46A1 (CYP46A1) or ...

© 2015, Sociedad Medica de Santiago. All Rights Reserved.Background: Plasma high density lipoproteins (HDL) are involved in reverse cholesterol transport mediated by the scavenger receptor class B type I (SR-BI). Nicotinic ...

•Cholesterol in the virion envelope is essential for dengue virus infectivity.•The four dengue serotypes are similarly inactivated by cholesterol-extracting drugs.•Dengue virus uncoating is blocked in infection with ...