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Development of multi-epitope peptide-based vaccines against SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic involving so far more than 15 million infections and 630,211 deaths. Effective vaccines are urgently needed to prevent SARS-CoV-2 infections. ...
Development of multi-epitope peptide-based vaccines against SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic
involving so far more than 15 million infections and 630,211 deaths. Effective vaccines are
urgently needed to prevent SARS-CoV-2 infections. ...
A Systematic, Unbiased Mapping of CD8+ and CD4+ T Cell Epitopes in Yellow Fever Vaccinees
(Frontiers Media S.A., 2020-08)
Examining CD8+ and CD4+ T cell responses after primary Yellow Fever vaccination in a cohort of 210 volunteers, we have identified and tetramer-validated 92 CD8+ and 50 CD4+ T cell epitopes, many inducing strong and prevalent ...
Development of bióinformatics tools to analyse peptide-protein interactións: immunoinformatics applicatións in next generatión vaccine design
(2017)
Epitope-based vaccines (EVs) make use of short, antigen-derived peptides corresponding
to epitopes that are administered lo trigger a protective humoral (B-cell epitopes) and/or
cellular (T-cell epitopes) immune response. ...
Bioinformatics tools for the prediction of T-cell epitopes
(Springer, 2018-05)
T-cell responses are activated by specific peptides, called epitopes, presented on the cell surface by MHC molecules. Binding of peptides to the MHC is the most selective step in T-cell antigen presentation and therefore ...
PREDIVAC : CD4+ T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity
(2013-02-14)
Background: CD4+ T-cell epitopes play a crucial role in eliciting vigorous protective immune responses during peptide (epitope)-based vaccination. The prediction of these epitopes focuses on the peptide binding process by ...
Sampling SARS-CoV-2 Proteomes for Predicted CD8 T-Cell Epitopes as a Tool for Understanding Immunogenic Breadth and Rational Vaccine Design
(Frontiers in Bioscience, 2021-02-19)
Predictive models for vaccine design have become a powerful and necessary resource for the expeditiousness design of vaccines to combat the ongoing SARS-CoV-2 global pandemic. Here we use the power of these predicted models ...
Identification and HLA-tetramer-validation of human CD4+ and CD8+ T cell responses against CMV proteins IE1 and IE2
(Public Library of Science, 2014-04)
Human cytomegalovirus (HCMV) is an important human pathogen. It is a leading cause of congenital infection and a leading infectious threat to recipients of solid organ transplants as well as of allogeneic hematopoietic ...
SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8+ T cell activation in COVID-19 patients
(American Association for the Advancement of Science, 2021-04)
T cells are important for effective viral clearance, elimination of virus-infected cells and long-term disease protection. To examine the full-spectrum of CD8+ T cell immunity in COVID-19, we experimentally evaluated 3141 ...