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Chronic use of marijuana decreases cannabinoid receptor binding and mRNA expression in the human brain
(Elsevier B.V., 2007-03-02)
Chronic exposure to Cannabis sativa (marijuana) produced a significant down-regulation of cannabinoid receptor in the postmortem human brain. the significant decrease in maximal binding capacity was not accompanied by ...
Ligand binding to CNS muscarinic receptor is transiently modified by convulsant 3-mercaptopropionic acid administration
(Springer/Plenum Publishers, 2000-06)
The administration of convulsant drugs has proven a powerful tool to study experimental epilepsy. We have already reported that the administration of convulsant 3-mercaptopropionic acid (mp) at 150 mg/kg enhances binding ...
Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles—A New Family of High Affinity CB1 Cannabinoid Ligands
(2013)
A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 ...
Genetic polymorphisms in vitamin D receptor, vitamin D-binding protein, toll-like receptor 2, nitric oxide synthase 2, and interferon-γ genes and its association with susceptibility to tuberculosis
(Associação Brasileira de Divulgação Científica, 2020)
Deamidation drives molecular aging of the SARS-CoV-2 spike protein receptor-binding motif
(American Society for Biochemistry and Molecular Biology, 2021-09)
The spike protein is the main protein component of the SARS-CoV-2 virion surface. The spike receptor-binding motif mediates recognition of the human angiotensin-converting enzyme 2 (hACE2) receptor, a critical step in ...
Inhibition of cannabinoid CB1 receptor upregulates Slc2a4 expression via nuclear factor-kappa B and sterol regulatory element-binding protein-1 in adipocytes
(BIOSCIENTIFICA LTDBRISTOL, 2012)
Evidences have suggested that the endocannabinoid system is overactive in obesity, resulting in enhanced endocannabinoid levels in both circulation and visceral adipose tissue. The blockade of cannabinoid receptor type 1 ...
How does confinement change ligand-receptor binding equilibrium? Protein binding in nanopores and nanochannels
(American Chemical Society, 2015-10)
We present systematic studies for the binding of small model proteins to ligands attached to the inner walls of long nanochannels and short nanopores by polymeric tethers. Binding of proteins to specific ligands inside ...
Design, synthesis, biological evaluation and binding mode modeling of benzimidazole derivatives targeting the cannabinoid receptor type 1
(Wiley-VCH Verlag, 2015)
© 2015 Wiley-VCH Verlag GmbH & Co. KGaA. A series of N-acyl-2,5-dimethoxyphenyl-1H-benzimidazoles were designed based on a CoMFA model for cannabinoid receptor type 1 (CB1) ligands. Compounds were synthesized and radioligand ...