artículo
Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles—A New Family of High Affinity CB1 Cannabinoid Ligands
Fecha
2013Registro en:
Jaime A. Mella-Raipán, Carlos F. Lagos, Gonzalo Recabarren-Gajardo, Christian Espinosa-Bustos, Javier Romero-Parra, Hernán Pessoa-Mahana, Patricio Iturriaga-Vásquez, C. David Pessoa-Mahana. Design, synthesis, binding and docking-based 3D-QSAR studies of 2-pyridylbenzimidazoles: a new family of high affinity CB1 cannabinoid ligands. Molecules. 2013;18:3972-4001.
10.3390/molecules18043972
WOS:000318020100024
Autor
Espinosa Bustos, Christian
Iturriaga Vásquez, Patricio
Lagos, Carlos
Mella Raipán, Jaime
Pessoa Mahana, Carlos David
Pessoa Mahana, Hernán
Recabarren Gajardo, Gonzalo Iván
Romero Parra, Javier Hernán
Institución
Resumen
A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 compounds displayed high affinitie