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New Cannabinoid receptor type 1 and 2 agonists and applications to understanding the endocannabinoid system: A chemical approach
(Academic Press, 2023)
The modulation of the endocannabinoid system by synthetic ligands has allowed mediating several pathophysiological processes in the control of various diseases. The work of many chemists in designing drugs that activate ...
New Pyridone-Based Derivatives as Cannabinoid Receptor Type 2 Agonists
(MDPI, 2021)
The activation of the human cannabinoid receptor type II (CB2R) is known to mediate analgesic and anti-inflammatory processes without the central adverse effects related to cannabinoid receptor type I (CB1R). In this work ...
Endocannabinoids, Through Opioids And Prostaglandins, Contribute To Fever Induced By Key Pyrogenic Mediators
(ACADEMIC PRESS INC ELSEVIER SCIENCESAN DIEGO, 2016)
Temporal and Behavioral Variability in Cannabinoid Receptor Expression in Outbred Mice Submitted to Ethanol-Induced Locomotor Sensitization Paradigm
(Wiley-Blackwell, 2013-09-01)
Background There is a close relationship between the endocannabinoid system and alcoholism. This study investigated possible differential expression of cannabinoid receptors CB1 (CB1R) and CB2 (CB2R) in an outbred mice ...
Exposure to cannabinoid agonist WIN 55,212-2 during early adolescence increases alcohol preference and anxiety in CD1 mice
(Pergamon-Elsevier Science Ltd, 2018-07)
The endocannabinoid (eCB) system is involved in the modulation of the reward system and participates in the reinforcing effects of different drugs of abuse, including alcohol. The most abundant receptor of the eCB system ...
Prenatal exposure to the CB1 and CB2 cannabinoid receptor agonist WIN 55,212-2 alters migration of early-born glutamatergic neurons and GABAergic interneurons in the rat cerebral cortex
(Wiley, 2014-05)
The endocannabinoid system, composed of cannabinoid receptors, endocannabinoids, and synthesis and degradation enzymes, is present since early stages of brain development. During this period, the endocannabinoid system is ...
New pyridone-based derivatives as cannabinoid receptor type 2 agonists
(MDPI, 2021)
The activation of the human cannabinoid receptor type II (CB2R) is known to mediate analgesic and anti-inflammatory processes without the central adverse effects related to cannabinoid receptor type I (CB1R). In this work ...
Further evidence for the neuroplastic role of cannabinoids: a study in organotypic hippocampal slice cultures
(Springer, 2015-08)
Endocannabinoid receptors CB1R and CB2R are present in the CNS and modulate synaptic activity. By using an in vitro model, two concentrations of CB1R agonist ACEA at 0.5 and 5 μM doses and CB1R antagonist AM251 at 1 and ...
Neuronal and synaptic morphological alterations in the hippocampus of cannabinoid receptor type 1 knockout mice
(Wiley-liss, div John Wiley & Sons Inc., 2020-07)
Cannabinoid receptor type 1 (CB1R) modulates synaptic activity and is widely distributed in brain areas such as the hippocampus, cerebellum, cerebral cortex, and striatum, among others. CB1R is involved in processes such ...