Article
Cannabinoid receptors on peripheral leukocytes from patients with schizophrenia: Evidence for defective immunomodulatory mechanisms
Registro en:
CARLI, Salvina Maria de Campos et al. Cannabinoid receptors on peripheral leukocytes from patients with schizophrenia: Evidence for defective immunomodulatory mechanisms. J Psychiatr Res., v. 87, p. 44-52, 2017
0022-3956
10.1016/j.jpsychires.2016.12.001
Autor
Carli, Salvina Mariade Campos
Araújo, Marcio Sobreira
Silveira, Amanda Cardoso de Oliveira
Rezende, Vítor Bortolo de
Rocha, Natalia Pessoa
Ferretjans, Rodrigo
Santos, Rafael Ribeiro
Carvalho, Andrea Teixeira de
Martins Filho, Olindo Assis
Berke, Michael
Salgado, João Vinícius
Teixeira, Antonio Lucio
Resumen
OBJECTIVES: to evaluate cannabinoid receptors (CBRs) expression on peripheral immune cells, i.e., blood monocytes, neutrophils, lymphocytes, and NK cells, and their relationship to a wide range of serum cytokine levels in subjects with schizophrenia and controls.
METHODS: A sample of 55 people with chronic schizophrenia and 48 controls were enrolled in the study. The expression of the cannabinoid receptors CB1R and CB2R was evaluated in peripheral blood leukocytes by flow cytometry. Serum levels of cytokines/chemokines were simultaneously analyzed by cytometric bead array.
RESULTS: We found higher expression of cannabinoid receptors on cells of the innate immune system in subjects with schizophrenia when compared with controls. Serum levels of interleukin-4 (IL-4), IL-6, IL-10, IL-17, interferon (IFN-γ), and (C-X-C motif) ligand 10/interferon gamma-induced protein 10 (CXCL10/IP10) were decreased, while levels of the chemokine (C-C motif) ligand 2/monocyte chemoattractant protein-1 (CCL2/MCP-1) were increased in the schizophrenia group in comparison with controls. Patients with schizophrenia showed simpler correlation network between cytokines and CBRs expression than controls.
CONCLUSION: Patients with schizophrenia showed increased CBRs expression in cells of the innate immune system and simpler correlation network between cytokines and CBRs expression when compared with controls. These results suggest a defective endocannabinoid system-mediated immunomodulation in patients with schizophrenia. 2022-01-01