Buscar
Mostrando ítems 1-10 de 396
Biophysical characterization of the interaction between M2-1 protein of hRSV and quercetin
(2017-02-01)
hRSV is the major causative agent of acute respiratory infections. Among its eleven proteins, M2-1 is a transcription antiterminator, making it an interesting target for antivirals. Quercetin is a flavonol which inhibits ...
Biophysical characterization and molecular phylogeny of human KIN protein
(Springer, 2019-10-01)
The DNA/RNA-binding KIN protein was discovered in 1989, and since then, it has been found to participate in several processes, e.g., as a transcription factor in bacteria, yeasts, and plants, in immunoglobulin isotype ...
Biophysical and socioeconomic factors influencing soil carbon stocks: a global assessment
(Springer, 2020-07-24)
Soil is the most important terrestrial carbon (C) reservoir but is greatly impacted by land use change (LUC). Previous analyses of LUC impacts on soil C have focused on biophysical variables, leaving aside the influence ...
A computational study of the protein-ligand interactions in CDK2 inhibitors: Using quantum mechanics/molecular mechanics interaction energy as a predictor of the biological activity
(Biophysical Society, 2007)
We report a combined quantum mechanics/molecular mechanics (QM/MM) study to determine the protein-ligand interaction energy between CDK2 (cyclin-dependent kinase 2) and five inhibitors with the N2-substituted 6-cyclohexy ...
Radiation Technology in Health Sciences at IPEN
(Sociedade Brasileira de Bioqu??mica e Biologia Molecular (SBBq), 2022)
The cytokine il‐1β and piperine complex surveyed by experimental and computational molecular biophysics
(2020-09-01)
The bioactive piperine, a compound found in some pepper species, has been widely studied because of its therapeutic properties that include the inhibition of an important inflammation pathway triggered by interleukin‐1 ...
Harmonic convergence coordinates swarm mating by enhancing mate detection in the malaria mosquito Anopheles gambiae
(Springer Nature, 2021)
The mosquito Anopheles gambiae is a major African malaria vector, transmitting parasites responsible for significant mortality and disease burden. Although flight acoustics are essential to mosquito mating and present ...
Biochemical and biophysical characterization of the RVB-1/RVB-2 protein complex, the RuvBL/RVB homologues in Neurospora crassa
(2021-12-01)
The RVB proteins, composed of the conservative paralogs, RVB1 and RVB2, belong to the AAA+ (ATPases Associated with various cellular Activities) protein superfamily and are present in archaea and eukaryotes. The most ...
First trimester screening for preterm and term pre-eclampsia by maternal characteristics and biophysical markers in a low-risk population
(Blackwell Publishing, 2018)
© 2018 Japan Society of Obstetrics and Gynecology Aim: To develop a combined predictive model for preterm and term pre-eclampsia (PE) during the first trimester of pregnancy. Methods: This investigation was a nested ...