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BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α
(2012)
Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the unfolded protein response (UPR) stress sensor inositol-requiring enzyme 1α(IRE1α), which functions as an endoribonuclease that splices the ...
Activation of the lytic program of the Epstein–Barr virus in Burkitt's lymphoma cells leads to a two steps downregulation of expression of the proapoptotic protein BimEL, one of which is EBV-late-gene expression dependent
(Virology 387 (2009) (1) p.41.49, 2009-02-28)
The Epstein–Barr virus (EBV) generally latently infects its target cells with expression of genes conferring resistance to apoptosis. However, the modulation of apoptotic signals during lytic cycle remains poorly understood. ...
Activation of the lytic program of the Epstein–Barr virus in Burkitt's lymphoma cells leads to a two steps downregulation of expression of the proapoptotic protein BimEL, one of which is EBV-late-gene expression dependent
(Virology 387 (2009) (1) p.41.49, 2009-02-28)
The Epstein–Barr virus (EBV) generally latently infects its target cells with expression of genes conferring resistance to apoptosis. However, the modulation of apoptotic signals during lytic cycle remains poorly understood. ...
Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis
(2012)
Activation of the unfolded protein response sensor PKR-like endoplasmic reticulum kinase (Perk) attenuates endoplasmic reticulum (ER) stress levels. Conversantly, if the damage is too severe and ER function cannot be ...
The proapoptotic protein Bim is up regulated by 1α,25-dihydroxyvitamin D3 and its receptor agonist in endothelial cells and transformed by viral GPCR associated to Kaposi sarcoma
(Elsevier Science Inc, 2015-08)
We have previously shown that 1a,25-dihydroxyvitamin D3 [1a,25(OH)2D3] and its less calcemic analogTX 527 induce apoptosis via caspase-3 activation in endothelial cells (SVEC) and endothelial cells transformedby the viral ...
Production and purification of alkaline xylanases
(Elsevier Sci LtdOxfordInglaterra, 1999)
Topological properties and in vitro identification of essential nodes of the Paclitaxel and Vincristine interactomes in PC-3 cells
(2019)
Background: Microtubule-targeting agents (MTAs) disrupt microtubule dynamics, thereby inducing apoptosis via mitochondrial pathway activation through the modulation in the expression of the Bcl-2 family. Methods: To describe ...
Combretastatin A-4 induces p53 mitochondrial-relocalisation independent-apoptosis in non-small lung cancer cells
(2014)
CombretastatinA-4(CA-4)isoneofthemosteffectiveagentsusedinchemotherapy.Nevertheless,thecontributionofp53and Bim proteins in the CA-4-induced apoptosis in non-small lung cancer cells (NSCLC) remains unresolved, specifically ...