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Structural studies of the protein endostatin in fusion with BAX BH3 death domain, a hybrid that presents enhanced antitumoral activity
(2017-05-01)
Endostatin (ES) is an antiangiogenic protein that exhibits antitumor activity in animal models. However, the activity observed in animals was not observed in human clinical trials. ES-BAX is a fusion protein composed of ...
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α
(2012)
Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the unfolded protein response (UPR) stress sensor inositol-requiring enzyme 1α(IRE1α), which functions as an endoribonuclease that splices the ...
Proteoma quantitativo para identificação de potenciais fatores de virulência em Leishmania infantum
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em ParasitologiaUFMG, 2017-07-12)
Leishmania infantum is the protozoan responsible for Visceral Leishmaniasis in Americas and Europe, a serious disease that can be fatal if untreated. Human cases range from subclinical infection, with an undetermined number ...
Abordagem proteômica para identificação de fatores de virulência em duas cepas de Leishmania infantum
(Universidade Federal de Minas GeraisUFMG, 2013-02-19)
Leishmania infantum, synonymy with L. chagasi, is the protozoan responsible for Visceral Leishmaniasis in the Americas and Europe, a serious disease that can be fatal if untreated. Human cases range from subclinical ...
Increased tyrosine phosphorylation causes redistribution of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia
(Gustav Fischer VerlagJenaAlemanha, 1998)