Buscar
Mostrando ítems 1-10 de 75
The plastic phenomenon underlying the associative processes in the addictive properties of diazepam and other psychoactive drugs
(Bentham Science Publishers, 2009-12)
Benzodiazepines are commonly prescribed for the therapy of disorders such as anxiety and sleep disturbance, but develop dependence in many patients. In this review we discuss the impact of different brain areas that modulate ...
Immediate increase in benzodiazepine binding in rat brain after a single brief experience in the plus maze: a paradoxical effect
(Elsevier B.V., 1999-07-02)
A single drug-free experience in the elevated plus-maze is well documented to reduce the behavioral effects of benzodiazepines (BZs) in subsequent tests. To ascertain the possible role of altered BZ receptor binding to in ...
Flavonoids as GABAA receptor ligands: the whole story?
(Dove Medical Press, 2012-01)
Benzodiazepines are the most widely prescribed class of psychoactive drugs in current therapeutic use, despite the important unwanted side effects that they produce, such as sedation, myorelaxation, ataxia, amnesia, and ...
Adaptive changes in the rat hippocampal glutamatergic neurotransmission are observed during long-term treatment with lorazepam
(Springer, 2003-12)
Rationale: Chronic treatment with benzodiazepines induces tolerance to most of their pharmacological effects. The best-studied neurochemical correlation to this phenomenon involves GABAergic adaptive changes. However, some ...
Assessing the efficacy of melatonin to curtail benzodiazepine/Z drug abuse
(Elsevier, 2016-07)
The abuse of benzodiazepine (BZP) and Z drugs has become, due to the tolerance and dependence they produce, a serious public health problem. Thirty years ago, we demonstrated in experimental animals the interaction of ...
GABA induces activity dependent delayed-onset uncoupling of GABA/benzodiazepine site interactions in neocortical neurons
(American Society for Biochemistry and Molecular Biology, 2005-06)
Changes in the function of type A γ-aminobutyric acid receptors (GABAARs) are associated with neuronal development and tolerance to the sedative-hypnotic effects of GABAAR positive modulators. Persistent activation of ...
Similar anxiolytic-like effects following intra-amygdala infusions of benzodiazepine receptor agonist and antagonist: Evidence for the release of an endogenous benzodiazepine inverse agonist in mice exposed to elevated plus-maze test
(Elsevier B.V., 2009-04-24)
Previous studies have demonstrated that microinjections of midazolam, a benzodiazepine receptor agonist, into the amygdala produce anxiolytic-like effects in elevated plus-maze (EPM)-naive rodents. However, systemic or ...
Similar anxiolytic-like effects following intra-amygdala infusions of benzodiazepine receptor agonist and antagonist: Evidence for the release of an endogenous benzodiazepine inverse agonist in mice exposed to elevated plus-maze test
(Elsevier B.V., 2009-04-24)
Previous studies have demonstrated that microinjections of midazolam, a benzodiazepine receptor agonist, into the amygdala produce anxiolytic-like effects in elevated plus-maze (EPM)-naive rodents. However, systemic or ...
Uso indiscriminado de benzodiazepínico: proposta de intervenção
(Universidade Federal de Minas GeraisUFMG, 2014-06-07)
Benzodiazepines ( BZDs ) are psychoactive drugs classically used to treat anxiety and sleep disorders. Became available from the 1960s and, since then, are among the most prescribed in the world. It is estimated that 50 ...