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Convergent evolution led ribosome inactivating proteins to interact with ribosomal stalk
(Elsevier, 2012-01)
Ribosome-inactivating proteins (RIPs) inhibit protein synthesis by depurinating an adenine on the sarcin–ricin loop (SRL) of the large subunit ribosomal RNA. Several RIPs interact with the C-terminal end of ribosomal stalk ...
The C-terminal end of P proteins mediates ribosome inactivation by trichosanthin but does not affect the pokeweed antiviral protein activity
(Academic Press Inc Elsevier Science, 2008-05)
Ribosome inactivating proteins (RIPs) inhibit protein synthesis depurinating a conserved residue in the sarcin/ricin loop of ribosomes. Some RIPs are only active against eukaryotic ribosomes, but other RIPs inactivate with ...
Trypanosoma cruzi: High ribosomal resistance to trichosanthin inactivation
(Academic Press Inc Elsevier Science, 2008-03)
Trypanosoma cruzi is the parasite causing Chagas Disease. Several results already published suggest that T. cruzi ribosomes have remarkable differences with their mammalian counterparts. In the present work, we showed that ...
Revising the Taxonomic Distribution, Origin and Evolution of Ribosome Inactivating Protein Genes
(Public Library of Science, 2013-07)
Ribosome inactivating proteins are enzymes that depurinate a specific adenine residue in the alpha-sarcin-ricin loop of the large ribosomal RNA, being ricin and Shiga toxins the most renowned examples. They are widely ...
Metazoan Ribosome Inactivating Protein encoding genes acquired by Horizontal Gene Transfer
(Nature Publishing Group, 2017-12)
Ribosome inactivating proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine residue in the conserved sarcin/ricin loop of 28S rRNA. These enzymes are widely distributed among plants and their presence ...
Isolation and characterization of four type 2 ribosome inactivating pulchellin isoforms from Abrus pulchellus seeds
(BLACKWELL PUBLISHING, 2008)
Abrus pulchellus seeds contain at least seven closely related and highly toxic type 2 ribosome-inactivating pulchellins, each consisting of a toxic A-chain linked to a sugar binding B-chain. In the present study, four ...
Antifungal activity of the ribosome-inactivating protein BE27 from sugar beet (Beta vulgaris L.) against the green mould Penicillium digitatum
(Wiley-Blackwell, 2016-02)
The ribosome-inactivating protein BE27 from sugar beet (Betavulgaris L.) leaves is an apoplastic protein induced by signallingcompounds, such as hydrogen peroxide and salicylic acid, whichhas been reported to be involved ...
The role of the C-terminal region of pulchellin A-chain in the interaction with membrane model systems
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Pulchellin is a Ribosome Inactivating Protein containing an A-chain (PAC), whose toxic activity requires crossing the endoplasmic reticulum (ER) membrane. In this paper, we investigate the interaction between recombinant ...
The role of the C-terminal region of pulchellin A-chain in the interaction with membrane model systems
(Elsevier B.V., 2012-01-01)
Pulchellin is a Ribosome Inactivating Protein containing an A-chain (PAC), whose toxic activity requires crossing the endoplasmic reticulum (ER) membrane. in this paper, we investigate the interaction between recombinant ...