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Comparing activity, toxicity and model membrane interactions of Jelleine-I and Trp/Arg analogs: analysis of peptide aggregation
(2020-05-01)
Increasing resistance in antibiotic and chemotherapeutic treatments has been pushing studies of design and evaluation of bioactive peptides. Designing relies on different approaches from minimalist sequences and endogenous ...
Peptide based therapeutics and their use for the treatment of neurodegenerative and other diseases
(Elsevier Masson SAS, 2018)
PE and PS lipids synergistically enhance membrane poration by a peptide with anticancer properties
(Elsevier B. V., 2015-09-01)
Polybia-MP1 (MP1) is a bioactive host-defense peptide with known anticancer properties. Its activity is attributed to excess serine (phosphatidylserine (PS)) on the outer leaflet of cancer cells. Recently, higher quantities ...
Production of Cell-Penetrating Peptides in Escherichia coli Using an Intein-Mediated System
(Springer, 2015)
Cell-penetrating peptides are molecules with the ability to cross membranes and
enter cells. Attention has been put on these peptides as a tool for drug delivery research, as they
are able to serve as delivery vectors ...
Phosphatidylserine lipids and membrane order precisely regulate the activity of Polybia-MP1 peptide
(2017-06-01)
Polybia-MP1 (IDWKKLLDAAKQIL-NH2) is a lytic peptide from the Brazilian wasp venom with known anti-cancer properties. Previous evidence indicates that phosphatidylserine (PS) lipids are relevant for the lytic activity of ...
CIGB-300 anticancer peptide regulates the protein kinase CK2-dependent phosphoproteome
(Springer, 2020-05-13)
Casein-kinase CK2 is a Ser/Thr protein kinase that fosters cell survival and proliferation of malignant cells. The CK2 holoenzyme, formed by the association of two catalytic alpha/alpha’ (CK2α/CK2α’) and two regulatory ...
Comparative analysis reveals amino acids critical for anticancer activity of peptide CIGB-552
(John Wiley & Sons Ltd, 2016-11)
Because of resistance development by cancer cells against current anticancer drugs, there is a considerable interest in developing novel antitumor agents. We have previously demonstrated that CIGB-552, a novel cell-penetrating ...
Protonectin peptides target lipids, act at the interface and selectively kill metastatic breast cancer cells while preserving morphological integrity
(2021-11-01)
Despite the need for innovative compounds as antimicrobial and anticancer agents, natural sources of peptides remain underexplored. Protonectin (PTN), a cationic dodecapeptide of pharmacological interest, presents large ...