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Molecular implications of adenosine in obesity
(2017)
Adenosine has broad activities in organisms due to the existence of multiple receptors, the differential adenosine concentrations necessary to activate these receptors and the presence of proteins able to synthetize, degrade ...
Two new adenosine receptor antagonists for the treatment of Parkinson's disease: istradefylline versus tozadenant
(Taylor & Francis, 2014-03)
INTRODUCTION: Adenosine A2A receptors are localized in the brain, mainly within the caudate and putamen nuclei of the basal ganglia. Their activation leads to stimulation of the 'indirect' pathway. Conversely, administration ...
Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels
(2017)
Adenosine as well as agonists and antagonists for the four adenosine receptor subtypes (A1R, A2AR, A2BR and A3R) play a role in several key physiological and pathophysiological processes, including the regulation of vascular ...
Adenosine in the lateral hypothalamus/perifornical area does not participate on the CO2 chemoreflex
(2020-05-01)
The Lateral Hypothalamus/Perifornical Area (LH/PFA) has been shown to be involved with the hypercapnic ventilatory response, in a state-dependent manner. We have demonstrated that purinergic signaling through ATP in the ...
Adenosine receptors: modulators of lipid availability that are controlled by lipid levels
(2017)
Adenosine as well as agonists and antagonists for the four adenosine receptor subtypes (A1R, A2AR, A2BR and A3R) play a role in several key physiological and pathophysiological processes, including the regulation of vascular ...
Molecular implications of adenosine in obesity
(2017-06)
Adenosine has broad activities in organisms due to the existence of multiple receptors, the differential adenosine concentrations necessary to activate these receptors and the presence of proteins able to synthetize, degrade ...
Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A(2B) adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia
(W B SAUNDERS CO LTD, 2008)
Pre-eclampsia is associated with elevated maternal blood pressure and proteinuria, altered fetal growth, and increased plasma adenosine concentration in the mother and the fetus. Human equilibrative nucleoside transporters ...
A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A1 receptors and enhances consolidation of step-down avoidance
(Elsevier Science, 2012-10)
Adenosine A1 receptor antagonists are of potential value in the treatment of cognitive dysfunction. We have developed compound AJ23 (7-methyl-1-phenyl-1,8-dihydro-pyrazolo-(3,4d)(1,2,4)-triazolo(1,5a)-pyrimidin-4-one) as ...
Structural determinants of efficacy at A3 adenosine receptors: Modification of the ribose moiety
(Pergamon-Elsevier Science Ltd, 2004-03)
We have found previously that structural features of adenosine derivatives, particularly at the N6- and 2-positions of adenine, determine the intrinsic efficacy as A3 adenosine receptor (AR) agonists. Here, we have probed ...