Artículo
Molecular implications of adenosine in obesity
Fecha
2017-06Autor
Universidad San Sebastián
Universidad San Sebastián
Universidad San Sebastián
Universidad San Sebastián
Universidad San Sebastián
Universidad San Sebastián
Pardo, Fabián
Villalobos-Labra, Roberto
Chiarello, Delia I.
Salsoso, Rocío
Toledo, Fernando
Gutierrez, Jaime
Leiva, Andrea
Sobrevia, Luis
Institución
Resumen
Adenosine has broad activities in organisms due to the existence of multiple receptors, the differential adenosine concentrations necessary to activate these receptors and the presence of proteins able to synthetize, degrade or transport this nucleoside. All adenosine receptors have been reported to be involved in glucose homeostasis, inflammation, adipogenesis, insulin resistance, and thermogenesis, indicating that adenosine could participate in the process of obesity. Since adenosine seems to be associated with several effects, it is plausible that adenosine participates in the initiation and development of obesity or may function to prevent it. Thus, the purpose of this review was to explore the involvement of adenosine in adipogenesis, insulin resistance and thermogenesis, with the aim of understanding how adenosine could be used to avoid, treat or improve the metabolic state of obesity. Treatment with specific agonists and/or antagonists of adenosine receptors could reverse the obesity state, since adenosine receptors normalizes several mechanisms involved in obesity, such as lipolysis, insulin sensitivity and thermogenesis. Furthermore, obesity is a preventable state, and the specific activation of adenosine receptors could aid in the prevention of obesity. Nevertheless, for the treatment of obesity and its consequences, more studies and therapeutic strategies in addition to adenosine are necessary.
Materias
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Guía infográfica de las aves del campus de la Pontificia Universidad Javeriana : Sede central
Echeverry-Galvis, Maria Angela; Cortés Cano, Juan Sebastián; Juan Sebastián, Sergio Andrés; Zapata Montoya, Sebastián; Botiva, Daniel Yesid; Linero, Daniela; Orozco, Daniela; Medina, Juan Sebastián; Sánchez, Juan Sebastián; Zuluaga, Juliana; Gómez, Laura María; Erazo, Paula Andrea; Ortegón, Salomé; Niño, Stephanie; Bocanegra, Valentina; Cardona, Valentina; Rincón, Víctor Julio; Moreno, Johan Sebastian; Jiménez, ValeriaEn las áreas urbanas las aves les dan a los ciudadanos un contacto directo con la vida silvestre. Su presencia es esencial para la polinización de jardines y huertas urbanas, para el control de poblaciones de roedores y ... -
Guía infográfica de las aves del campus de la Pontificia Universidad Javeriana : Sede central
Echeverry-Galvis, Maria Angela; Cortés Cano, Juan Sebastián; Juan Sebastián, Sergio Andrés; Zapata Montoya, Sebastián; Botiva, Daniel Yesid; Linero, Daniela; Orozco, Daniela; Medina, Juan Sebastián; Sánchez, Juan Sebastián; Zuluaga, Juliana; Gómez, Laura María; Erazo, Paula Andrea; Ortegón, Salomé; Niño, Stephanie; Bocanegra, Valentina; Cardona, Valentina; Rincón, Víctor Julio; Moreno, Johan Sebastian; Jiménez, ValeriaEn las áreas urbanas las aves les dan a los ciudadanos un contacto directo con la vida silvestre. Su presencia es esencial para la polinización de jardines y huertas urbanas, para el control de poblaciones de roedores y ... -
Niveles de empatía en estudiantes de Odontología de la Universidad San Sebastián, Concepción, Chile
Universidad San Sebastián; Universidad San Sebastián; Universidad San Sebastián; Torres-Martínez, Pilar Alejandra; Barrios-Penna, Carolina Alejandra; Fonseca-Molina, Juan Fernando; Díaz-Narváez, Víctor Patricio; González-Cruz, Sebastián Alejandro (2017)Introduction: The training of future dentists should consider developing empathy while they are still students. The first step to consider such training is to assess empathic behavior. Objective: To measure levels of empathy ...