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Processo antissolvente supercrítico para obtenção de dispersões sólidas
(Universidade Estadual Paulista (Unesp), 2014-03-28)
In this study we proposed the use of supercritical antisolvent process (SAS), in which carbon dioxide was selected as antisolvent agent, to obtain drug controlled release system. Factorial 32 experimental design use the ...
A novel gastroretentive floating system for zidovudine, based on calcium-silicate beads
(Academic Journals, 2013)
The aim of the research effort entertained herein was to develop, evaluate and fully characterize a multiparticulate floating gastroretentive system for the modified release of zidovudine (AZT), an antiretroviral drug. AZT ...
Preparation and Characterization of Chitosan Nanoparticles for Zidovudine Nasal Delivery
(Amer Scientific Publishers, 2015-01-01)
Zidovudine (AZT) is the antiretroviral drug most frequently used for the treatment of Acquired Immunodeficiency Syndrome. Its low oral bioavailability demands the development of innovative strategies to overcome the first ...
LC Evaluation of In Vitro Release of AZT from Microemulsions
(Vieweg, 2009-06-01)
A reversed phase LC method was developed and validated to analyze the in vitro release of AZT from microemulsions. A mobile phase of acetonitrile:water (15:85) was used. The method validation showed good selectivity and ...
LC Evaluation of In Vitro Release of AZT from Microemulsions
(Vieweg, 2009-06-01)
A reversed phase LC method was developed and validated to analyze the in vitro release of AZT from microemulsions. A mobile phase of acetonitrile:water (15:85) was used. The method validation showed good selectivity and ...
Processo antissolvente supercrítico para obtenção de dispersões sólidas
(Universidade Estadual Paulista (UNESP), 2014)
Processo antissolvente supercrítico para obtenção de dispersões sólidas
(Universidade Estadual Paulista (Unesp), 2014)
Antiretroviral activity and cytotoxicity of novel zidovudine (AZT) derivatives and the relation to their chemical structure
(Elsevier Science, 2002-10)
Zidovudine (AZT) was the first nucleoside analogue licensed for the treatment of HIV infection. Efforts have continuously been made to improve the therapeutic characteristics of this drug, most of them focussed on prodrugs ...
A novel gastroretentive floating system for zidovudine, based on calcium-silicate beads
(Academic Journals, 2016)
Pharmaceutical polymorphism of a 5´-O-oxalatoyl prodrug of zidovudine (azidothymidine)
(Open Science Publishers LLP, 2020-03)
The importance of polymorphism in pharmaceuticals makes its study relevant. The aim of this study was to investigate the solid-state forms in which 3´-azido-2´,3´-dideoxi-5´-O-oxalatoyl-thymidinic acid (AZT-Ac), a zidovudine ...