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Phase Behavior of Ascorbyl Palmitate Coagels Loaded with Oligonucleotides as a New Carrier for Vaccine Adjuvants
(Springer Heidelberg, 2016-07-26)
In this work, the phase behavior variations of an ascorbyl palmitate (Asc16) system in aqueous solution were analyzed when immunologically active hydrophilic compounds (CpG and OVA) were introduced. This study was carried ...
A liquid crystal of ascorbyl palmitate, used as vaccine platform, provides sustained release of antigen and has intrinsic pro-inflammatory and adjuvant activities which are dependent on MyD88 adaptor protein
(Elsevier Science, 2015-09-28)
Modern subunit vaccines require the development of new adjuvant strategies. Recently,32 we showed that CpG-ODN formulated with a liquid crystal nanostructure formed by self33assembly of 6-O-ascorbyl palmitate (Coa-ASC16) ...
Development and validation of a high performance liquid 4 chromatography method for oligodeoxynucleotides determination 5 in a novel coagel-based formulation
(Elsevier, 2015-03)
The therapeutic benefit of phosphorothioate oligodeoxynucleotides (PS-ODN) containing immune stimulatory sequences has been demonstrated in animal models of cancer and infection. Several tools are available for the ...
Vitamin C based nanostructures: potential utility in ocular and transdermal therapy
(American Scientific Publishers, 2013-02)
Alkyl vitamin C derivatives (ASCn) combine in their structure a lipophilic and a hydrophilic moiety and exhibit properties of typical surfactant molecules. Self-assembly properties of ASCn depend on the length of n-alkyl ...
Adjuvant activity of CpG-ODN formulated as a liquid crystal
(Elsevier, 2013)
A Vaccine Based on Kunitz-Type Molecule Confers Protection Against Fasciola hepatica Challenge by Inducing IFN-γ and Antibody Immune Responses Through IL-17A Production
(Frontiers Media S.A., 2020-10)
Fasciola hepatica is helminth parasite found around the world that causes fasciolosis, a chronic disease affecting mainly cattle, sheep, and occasionally humans. Triclabendazole is the drug of choice to treat this parasite. ...
Desarrollo de un complejo de inclusión molecular de fármacos a partir de almidón nativo
(Bogotá - Ciencias - Maestría en Ciencias FarmacéuticasDepartamento de FarmaciaUniversidad Nacional de Colombia - Sede Bogotá, 2020-08-16)
El almidón es un polímero biodegradable y biocompatible cuyas investigaciones durante los últimos años lo proyectan como un material de partida prometedor para el desarrollo de sistemas de entrega de moléculas en el campo ...