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Vanillin enones as selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII: The out of the active site pocket for the design of selective inhibitors?
(Taylor & Francis Ltd, 2021-10-04)
New C-glycosides and a,b-unsaturated ketones incorporating the 4-hydroxy-3-methoxyphenyl (vanillin) moiety as inhibitors of carbonic anhydrase (CA, EC 4.2.1.1) isoforms have been investigated. The inhibition profile of ...
Effect of Selective Phosphodiesterase Inhibitors on the Rat Eosinophil Chemotactic Response In Vitro
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz., 2020)
Design of new quinolin-2-one-pyrimidine hybrids as sphingosine kinases inhibitors
(Academic Press Inc Elsevier Science, 2020-01)
Sphingosine-1-phosphate is now emerging as an important player in cancer, inflammation, autoimmune, neurological and cardiovascular disorders. Abundance evidence in animal and humans cancer models has shown that SphK1 is ...
Proteolytic Inhibitors: Implications on Microorganisms Development, Virulence and Pathogenesis
(Ingenta Connect, 2015)
Design, synthesis and evaluation of cholinesterase hybrid inhibitors using a natural steroidal alkaloid as precursor
(Academic Press Inc Elsevier Science, 2021-06-11)
To date, Alzheimers disease is the most alarming neurodegenerative disorder worldwide. This illness is multifactorialin nature and cholinesterase inhibitors have been the ones used in clinical treatments. In this context,many ...