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Base-Free Direct Synthesis of Alkynylphosphonates from Alkynes and H-Phosphonates Catalyzed by Cu2O
(American Chemical Society, 2016-03-04)
A simple and mild methodology for the direct synthesis of alkynylphosphonates is presented. The reaction of a variety of terminal alkynes with dialkyl phosphites in the presence Cu2O (14 mol %) led to the formation of the ...
The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer
(Pergamon-elsevier Science Ltd, 2015-09)
The active form of vitamin D3, calcitriol, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and prodifferentiating agent. However, when effective antitumor doses ...
Antitumoral effects of the alkynylphosphonate analogue of calcitriol EM1 on glioblastoma multiforme cells
(Pergamon-Elsevier Science Ltd, 2017-11)
Glioblastoma multiforme (GBM) is the worst and most common brain tumor, characterized by high proliferation and invasion rates. The current standard treatment is mainly based on chemoradiotherapy and this approach has ...
Structure-Activity Relationship Study of an Alkynylphosphonate and a Vynilphosphonate Analogues of Calcitriol
(Bentham Science Publishers, 2021-08-18)
Background: 1α,25-dihydroxy vitamin D3 (calcitriol) shows potent growth-inhibitory properties on different cancer cell lines, but its hypercalcemic effects have severely hampered its therapeutic application. Therefore, it ...
Alkynyl and β-ketophosphonates: Selective and potent butyrylcholinesterase inhibitors
(Academic Press Inc Elsevier Science, 2018-04)
A series of thirty-three alkynyl and β-ketophosphonates were evaluated for their in vitro acetyl- and butyryl-cholinesterase (AChE and BChE) inhibitory activities using Ellman´s spectrophotometric method. None of the ...
Síntese de derivados vinílicos e enínicos de fósforo e aplicação sintética de dissulfetos imidazolidínicos quirais em reações assimétricas
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2002-07-26)
In this work, we developed a method to prepare β-alkynylvinylphosphonates 3 via a
palladium-catalyzed cross-coupling reaction of β-n-butyltellurovinylphosphonates 2 with
terminal alkynes. The compounds 2 were prepared ...
Phosphonate analogues of 1, 25 dihydroxyvitamin D3 are promising candidates for antitumoural therapies
(Bentham Science Publishers, 2014-11-01)
The active metabolite of vitamin D, 1α, 25 dihydroxyvitamin D3 (calcitriol) is classically known to regulate calcium and phosphate homeostasis and bone mineralization. In addition, calcitriol has also been documented to ...