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Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results
(Massachusetts Medical Society, 2020)
BACKGROUND: World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs - remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a - in patients hospitalized with ...
ROLE of POSITION-9 and POSITION-10 in the ENDOTHELIN MOLECULE for BIOLOGICAL-ACTIVITY and DISCRIMINATION of RECEPTOR SUBTYPES
(Elsevier B.V., 1995-05-15)
The importance of residues 9 and 10 in endothelin-1 was assessed by studying the responses of the guinea-pig ileum to [Ala(9)]endothelin-1 and [Ala(10)]endothelin-1. Both analogues induced relaxation followed by contraction. ...
Effect of C-terminal and N-terminal dimerization and alanine scanning on antibacterial activity of the analogs of the peptide p-BthTX-I
(2022-03-01)
The peptide (p-BthTX-I)2 [(KKYRYHLKPFCKK)2] and its analog des-Lys12,Lys13-(p-BthTX-I)2 [(KKYRYHLKPFC)2] showed activity against bacteria and potential specificity against prokaryotic cells. In this study, we synthesized ...
Antiplasmodial activity study of angiotensin II via Ala scan analogs
(Wiley-Blackwell, 2014-08-01)
Angiotensin II (AII) as well as analog peptides shows antimalarial activity against Plasmodium gallinaceum and Plasmodium falciparum, but the exact mechanism of action is still unknown. This work presents the solid-phase ...
Direct thrombin inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in people with non-valvular atrial fibrillation
(Wiley, 2014)
BACKGROUND: Chronic anticoagulation with vitamin K antagonists (VKAs) prevents ischaemic stroke and systemic embolism in people with non-valvular atrial fibrillation (AF) but dose adjustment, coagulation monitoring and ...
Structure-activity relationship of 1-desamino-8-D-arginine vasopressin as an antiproliferative agent on human vasopressin V2 receptor-expressing cancer cells
(Spandidos Publications, 2014-04)
The synthetic nonapeptide 1-desamino-8-D-arginine vasopressin (dDAVP) can reduce tumor cell growth through agonist action on the vasopressin V2 receptor. A structure-antiproliferative activity relationship analysis of dDAVP ...
LH Response (in vivo and in vitro) to an LHRH Agonist Administered to Domestic Male Cats
(2003-07-01)
We investigated plasma luteinizing hormone (LH) concentration in domestic male cats challenged with Luteinizing Hormone Releasing Hormone Analog (LHRH-A) [des Gly10, (DTrp6)-LHRH ethylamide] that mediates the function of ...
LH Response (in vivo and in vitro) to an LHRH Agonist Administered to Domestic Male Cats
(2003-07-01)
We investigated plasma luteinizing hormone (LH) concentration in domestic male cats challenged with Luteinizing Hormone Releasing Hormone Analog (LHRH-A) [des Gly10, (DTrp6)-LHRH ethylamide] that mediates the function of ...
Hepatitis B virus surface antigen seroconversion in HIV-infected individual after pegylated interferon-alpha treatment: a case report
(Biomed Central LtdLondonInglaterra, 2013)